| http://purl.uniprot.org/citations/24074869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24074869 | http://www.w3.org/2000/01/rdf-schema#comment | "Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macrophage-specific deletion of NCoR instead results in an anti-inflammatory phenotype along with robust systemic insulin sensitization in obese mice. We present evidence that derepression of LXRs contributes to this paradoxical anti-inflammatory phenotype by causing increased expression of genes that direct biosynthesis of palmitoleic acid and ω3 fatty acids. Remarkably, the increased ω3 fatty acid levels primarily inhibit NF-κB-dependent inflammatory responses by uncoupling NF-κB binding and enhancer/promoter histone acetylation from subsequent steps required for proinflammatory gene activation. This provides a mechanism for the in vivo anti-inflammatory insulin-sensitive phenotype observed in mice with macrophage-specific deletion of NCoR. Therapeutic methods to harness this mechanism could lead to a new approach to insulin-sensitizing therapies."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.08.054"xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Lu M."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Auwerx J."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Oh D.Y."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Glass C.K."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Olefsky J.M."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Talukdar S."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Kaikkonen M.U."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Watkins S.M."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Dennis E.A."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Quehenberger O."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Bandyopadhyay G."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Spann N.J."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Fox J.N."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Patsouris D."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Lagakos W.S."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/author | "Armando A."xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/pages | "200-214"xsd:string |
| http://purl.uniprot.org/citations/24074869 | http://purl.uniprot.org/core/title | "NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids."xsd:string |