| http://purl.uniprot.org/citations/24075846 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24075846 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor Krüppel-like factor 4 (KLF4) can activate or repress gene expression in a cell-context dependent manner. We have previously shown that KLF4 inhibits the proliferation of naïve CD8(+) T cells in vitro downstream of the transcription factor ELF4. In this work, we describe a novel role of KLF4 in the differentiation of CD8(+) T cells upon infection. Loss of KLF4 had minimal effect on thymic T cell development and distribution of mature T cells in the spleen, blood, and lymph nodes. KLF4-deficient naïve CD8(+) T cells also displayed normal homeostatic proliferation upon adoptive transfer into lymphopenic hosts. However, activation of KLF4-deficient naïve CD8(+) T cells by in vitro TCR crosslink and co-stimulation resulted in increased proliferation. Furthermore, naïve KLF4-deficient OT-I CD8(+) T cells generated increased numbers of functional memory CD8(+) T cells compared to wild type OT-I CD8(+) T cells co-injected in the same recipient in both primary and recall responses to Listeria monocytogenes-OVA. Collectively, our data demonstrate that KLF4 regulates differentiation of functional memory CD8(+) T cells while sparing development and homeostasis of naïve CD8(+) T cells."xsd:string |
| http://purl.uniprot.org/citations/24075846 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.imlet.2013.09.008"xsd:string |
| http://purl.uniprot.org/citations/24075846 | http://purl.uniprot.org/core/author | "Park C.S."xsd:string |
| http://purl.uniprot.org/citations/24075846 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/24075846 | http://purl.uniprot.org/core/author | "Lee P.H."xsd:string |
| http://purl.uniprot.org/citations/24075846 | http://purl.uniprot.org/core/author | "Lacorazza H.D."xsd:string |
| http://purl.uniprot.org/citations/24075846 | http://purl.uniprot.org/core/author | "Mamonkin M."xsd:string |
| http://purl.uniprot.org/citations/24075846 | http://purl.uniprot.org/core/author | "Puppi M."xsd:string |
| http://purl.uniprot.org/citations/24075846 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24075846 | http://purl.uniprot.org/core/name | "Immunol Lett"xsd:string |
| http://purl.uniprot.org/citations/24075846 | http://purl.uniprot.org/core/pages | "94-101"xsd:string |
| http://purl.uniprot.org/citations/24075846 | http://purl.uniprot.org/core/title | "Differential roles of KLF4 in the development and differentiation of CD8+ T cells."xsd:string |
| http://purl.uniprot.org/citations/24075846 | http://purl.uniprot.org/core/volume | "156"xsd:string |
| http://purl.uniprot.org/citations/24075846 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24075846 |
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| http://purl.uniprot.org/uniprot/Q60793 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24075846 |
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