| http://purl.uniprot.org/citations/24077950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24077950 | http://www.w3.org/2000/01/rdf-schema#comment | "We showed that stop of flow triggers a mechanosignaling cascade that leads to the generation of reactive oxygen species (ROS); however, a mechanosensor coupled to the cytoskeleton that could potentially transduce flow stimulus has not been identified. We showed a role for KATP channel, caveolae (caveolin-1), and NADPH oxidase 2 (NOX2) in ROS production with stop of flow. Based on reports of a mechanosensory complex that includes platelet endothelial cell adhesion molecule-1 (PECAM-1) and initiates signaling with mechanical force, we hypothesized that PECAM-1 could serve as a mechanosensor in sensing disruption of flow. Using lungs in situ, we observed that ROS production with stop of flow was significantly reduced in PECAM-1(-/-) lungs compared with lungs from wild-type (WT) mice. Lack of PECAM-1 did not affect NOX2 activation machinery or the caveolin-1 expression or caveolae number in the pulmonary endothelium. Stop of flow in vitro triggered an increase in angiogenic potential of WT pulmonary microvascular endothelial cells (PMVEC) but not of PECAM-1(-/-) PMVEC. Obstruction of flow in lungs in vivo showed that the neutrophil infiltration as observed in WT mice was significantly lowered in PECAM-1(-/-) mice. With stop of flow, WT lungs showed higher expression of the angiogenic marker VEGF compared with untreated (sham) and PECAM-1(-/-) lungs. Thus PECAM-1 (and caveolae) are parts of the mechanosensing machinery that generates superoxide with loss of shear; the resultant ROS potentially drives neutrophil influx and acts as an angiogenic signal."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajplung.00123.2013"xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/author | "Yu K."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/author | "Noel J."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/author | "Chatterjee S."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/author | "Fisher A.B."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/author | "Hong N."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/author | "Sorokina E.M."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/author | "Rizzo V."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/author | "Tao J.Q."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/author | "Debolt K."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/author | "Delisser H."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/author | "Heayn M."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/name | "Am J Physiol Lung Cell Mol Physiol"xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/pages | "L805-18"xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/title | "PECAM-1 and caveolae form the mechanosensing complex necessary for NOX2 activation and angiogenic signaling with stopped flow in pulmonary endothelium."xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://purl.uniprot.org/core/volume | "305"xsd:string |
| http://purl.uniprot.org/citations/24077950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24077950 |
| http://purl.uniprot.org/citations/24077950 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24077950 |
| http://purl.uniprot.org/uniprot/#_D3Z0J2-mappedCitation-24077950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24077950 |
| http://purl.uniprot.org/uniprot/#_D3Z148-mappedCitation-24077950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24077950 |
| http://purl.uniprot.org/uniprot/#_E9Q7S3-mappedCitation-24077950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24077950 |