| http://purl.uniprot.org/citations/24080084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24080084 | http://www.w3.org/2000/01/rdf-schema#comment | "B-1 cells are an important cell population for the production of natural antibodies and front-line host defense. Here, we show that the MARVEL-domain-containing membrane protein CMTM7 (CKLF-like MARVEL transmembrane domain-containing 7) plays a critical role in BCR expression and survival in B-1a cells. We analyzed lymphocyte development in Rag1⁻/⁻ mice reconstituted with Cmtm7(flox/⁺) fetal liver cells because of the unexpected lethality of the Cmtm7(flox/⁺) heterozygotes. We found a mild reduction of serum IgM and a significantly reduced B-1a population in the peritoneal cavity of Rag1⁻/⁻ mice reconstituted with Cmtm7(flox/⁺) cells compared with those reconstituted with wild-type (WT) cells. The reduction of B-1a cells in Cmtm7(flox/⁺) mice was associated with reduced BCR expression and increased spontaneous cell death in these cells. In addition, both B-1a and B-1b cells derived from Cmtm7(flox/⁺) fetal liver cells contained a lower frequency of cells capable of spontaneously differentiating into IgM-secreting plasma cells than did those derived from WT fetal liver cells. Furthermore, Cmtm7(flox/⁺) B-1a and B-1b cells responded poorly to LPS-induced proliferation. In striking contrast to the defects in B-1 cells, Cmtm7(flox/⁺) B-2 cells did not show obvious abnormalities when compared with WT B-2 cells. These results demonstrate a specific role for CMTM7 in BCR expression and survival in B-1a cells."xsd:string |
| http://purl.uniprot.org/citations/24080084 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxt042"xsd:string |
| http://purl.uniprot.org/citations/24080084 | http://purl.uniprot.org/core/author | "Han W."xsd:string |
| http://purl.uniprot.org/citations/24080084 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/24080084 | http://purl.uniprot.org/core/author | "Wang J.Y."xsd:string |
| http://purl.uniprot.org/citations/24080084 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24080084 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/24080084 | http://purl.uniprot.org/core/pages | "47-57"xsd:string |
| http://purl.uniprot.org/citations/24080084 | http://purl.uniprot.org/core/title | "A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells."xsd:string |
| http://purl.uniprot.org/citations/24080084 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/24080084 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24080084 |
| http://purl.uniprot.org/citations/24080084 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24080084 |
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| http://purl.uniprot.org/uniprot/#_Q3THH0-mappedCitation-24080084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24080084 |
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| http://purl.uniprot.org/uniprot/#_P15919-mappedCitation-24080084 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24080084 |
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| http://purl.uniprot.org/uniprot/Q9ESD6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24080084 |