| http://purl.uniprot.org/citations/24085293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24085293 | http://www.w3.org/2000/01/rdf-schema#comment | "TNF-related apoptosis-inducing ligand (TRAIL) holds promise for treatment of cancer due to its ability to selectively kill cancer cells while sparing normal cells. Ligand-induced translocation of TRAIL receptors (TRAIL-R) 1 and 2 (also called DR4 and DR5, respectively) into lipid raft membrane microdomains is required for TRAIL-induced cell death by facilitating receptor clustering and formation of the death-inducing signaling complex, yet the underlying regulatory mechanisms remain largely unknown. We show here that the non-receptor tyrosine kinase Ack1, previously implicated in the spatiotemporal regulation of the EGF receptor, is required for TRAIL-induced cell death in multiple epithelial cell lines. TRAIL triggered a transient up-regulation of Ack1 and its recruitment to lipid rafts along with TRAIL-R1/2. siRNA-mediated depletion of Ack1 disrupted TRAIL-induced accumulation of TRAIL-R1/2 in lipid rafts and efficient recruitment of caspase-8 to the death-inducing signaling complex. Pharmacological inhibition of Ack1 did not affect TRAIL-induced cell death, indicating that Ack1 acts in a kinase-independent manner to promote TRAIL-R1/2 accumulation in lipid rafts. These findings identify Ack1 as an essential player in the spatial regulation of TRAIL-R1/2."xsd:string |
| http://purl.uniprot.org/citations/24085293 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.481507"xsd:string |
| http://purl.uniprot.org/citations/24085293 | http://purl.uniprot.org/core/author | "Mahajan N.P."xsd:string |
| http://purl.uniprot.org/citations/24085293 | http://purl.uniprot.org/core/author | "Ferby I."xsd:string |
| http://purl.uniprot.org/citations/24085293 | http://purl.uniprot.org/core/author | "Pilia G."xsd:string |
| http://purl.uniprot.org/citations/24085293 | http://purl.uniprot.org/core/author | "Linderoth E."xsd:string |
| http://purl.uniprot.org/citations/24085293 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24085293 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/24085293 | http://purl.uniprot.org/core/pages | "32922-32931"xsd:string |
| http://purl.uniprot.org/citations/24085293 | http://purl.uniprot.org/core/title | "Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death."xsd:string |
| http://purl.uniprot.org/citations/24085293 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/24085293 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24085293 |
| http://purl.uniprot.org/citations/24085293 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24085293 |
| http://purl.uniprot.org/uniprot/#_Q07912-mappedCitation-24085293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24085293 |
| http://purl.uniprot.org/uniprot/#_A0A5F9ZI29-mappedCitation-24085293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24085293 |
| http://purl.uniprot.org/uniprot/#_A0A499FJ16-mappedCitation-24085293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24085293 |
| http://purl.uniprot.org/uniprot/#_F8U8C0-mappedCitation-24085293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24085293 |
| http://purl.uniprot.org/uniprot/#_C1K3N4-mappedCitation-24085293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24085293 |
| http://purl.uniprot.org/uniprot/#_B7Z3M7-mappedCitation-24085293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24085293 |
| http://purl.uniprot.org/uniprot/#_B3KXJ4-mappedCitation-24085293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24085293 |
| http://purl.uniprot.org/uniprot/#_B5BU36-mappedCitation-24085293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24085293 |
| http://purl.uniprot.org/uniprot/#_O14763-mappedCitation-24085293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24085293 |
| http://purl.uniprot.org/uniprot/#_D3DSR9-mappedCitation-24085293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24085293 |
| http://purl.uniprot.org/uniprot/#_B7Z588-mappedCitation-24085293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24085293 |