| http://purl.uniprot.org/citations/24085347 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24085347 | http://www.w3.org/2000/01/rdf-schema#comment | "Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting both upper and lower motor neurons. The prognosis for ALS is extremely poor, but there is a limited course of treatment with only one approved medication. A most striking recent discovery is that TDP-43 is identified as a key molecule that is associated with both sporadic and familial forms of ALS. TDP-43 is not only a pathological hallmark, but also a genetic cause for ALS. Subsequently, a number of ALS-causative genes have been found. Above all, the RNA-binding protein, such as FUS, TAF15, EWSR1 and hnRNPA1, have structural and functional similarities to TDP-43, and physiological functions of some molecules, including VCP, UBQLN2, OPTN, FIG4 and SQSTM1, are involved in a protein degradation system. These discoveries provide valuable insight into the pathogenesis of ALS, and open doors for developing an effective disease-modifying therapy."xsd:string |
| http://purl.uniprot.org/citations/24085347 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00415-013-7112-y"xsd:string |
| http://purl.uniprot.org/citations/24085347 | http://purl.uniprot.org/core/author | "Ikenaka K."xsd:string |
| http://purl.uniprot.org/citations/24085347 | http://purl.uniprot.org/core/author | "Sobue G."xsd:string |
| http://purl.uniprot.org/citations/24085347 | http://purl.uniprot.org/core/author | "Ishigaki S."xsd:string |
| http://purl.uniprot.org/citations/24085347 | http://purl.uniprot.org/core/author | "Katsuno M."xsd:string |
| http://purl.uniprot.org/citations/24085347 | http://purl.uniprot.org/core/author | "Iguchi Y."xsd:string |
| http://purl.uniprot.org/citations/24085347 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24085347 | http://purl.uniprot.org/core/name | "J Neurol"xsd:string |
| http://purl.uniprot.org/citations/24085347 | http://purl.uniprot.org/core/pages | "2917-2927"xsd:string |
| http://purl.uniprot.org/citations/24085347 | http://purl.uniprot.org/core/title | "Amyotrophic lateral sclerosis: an update on recent genetic insights."xsd:string |
| http://purl.uniprot.org/citations/24085347 | http://purl.uniprot.org/core/volume | "260"xsd:string |
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