| http://purl.uniprot.org/citations/24091011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24091011 | http://www.w3.org/2000/01/rdf-schema#comment | "The Polycomb-group (PcG) repressive complex-1 (PRC1) forms microscopically visible clusters in nuclei; however, the impact of this cluster formation on transcriptional regulation and the underlying mechanisms that regulate this process remain obscure. Here, we report that the sterile alpha motif (SAM) domain of a PRC1 core component Phc2 plays an essential role for PRC1 clustering through head-to-tail macromolecular polymerization, which is associated with stable target binding of PRC1/PRC2 and robust gene silencing activity. We propose a role for SAM domain polymerization in this repression by two distinct mechanisms: first, through capturing and/or retaining PRC1 at the PcG targets, and second, by strengthening the interactions between PRC1 and PRC2 to stabilize transcriptional repression. Our findings reveal a regulatory mechanism mediated by SAM domain polymerization for PcG-mediated repression of developmental loci that enables a robust yet reversible gene repression program during development."xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2013.08.016"xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/author | "Isono K."xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/author | "Koseki H."xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/author | "Toyoda T."xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/author | "Bernstein B.E."xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/author | "Suzuki R."xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/author | "Endo T.A."xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/author | "Yamada D."xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/author | "Ishikura T."xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/author | "Ku M."xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/author | "Sharif J."xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/pages | "565-577"xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/title | "SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing."xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/24091011 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24091011 |
| http://purl.uniprot.org/citations/24091011 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24091011 |
| http://purl.uniprot.org/uniprot/#_A0A087WQQ3-mappedCitation-24091011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24091011 |
| http://purl.uniprot.org/uniprot/#_A0A087WP87-mappedCitation-24091011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24091011 |
| http://purl.uniprot.org/uniprot/#_A0A087WRE9-mappedCitation-24091011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24091011 |
| http://purl.uniprot.org/uniprot/#_B1AR14-mappedCitation-24091011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24091011 |
| http://purl.uniprot.org/uniprot/#_B1AS97-mappedCitation-24091011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24091011 |