| http://purl.uniprot.org/citations/24095276 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24095276 | http://www.w3.org/2000/01/rdf-schema#comment | "Phagophore maturation is a key step in the macroautophagy pathway, which is critical in many important physiological and pathological processes. Here we identified Drosophila N-ethylmaleimide-sensitive fusion protein 2 (dNSF2) and soluble NSF attachment protein (Snap) as strong genetic modifiers of mutant CHMP2B, an ESCRT-III component that causes frontotemporal dementia and autophagosome accumulation. Among several SNAP receptor (SNARE) genes, Drosophila syntaxin 13 (syx13) exhibited a strong genetic interaction with mutant CHMP2B. Knockdown of syntaxin 13 (STX13) or its binding partner Vti1a in mammalian cells caused LC3-positive puncta to accumulate and blocks autophagic flux. STX13 was present on LC3-positive phagophores induced by rapamycin and was highly enriched on multilamellar structures induced by dysfunctional ESCRT-III. Loss of STX13 also caused the accumulation of Atg5-positive puncta and the formation of multilamellar structures. These results suggest that STX13 is a genetic modifier of ESCRT-III dysfunction and participates in the maturation of phagophores into closed autophagosomes."xsd:string |
| http://purl.uniprot.org/citations/24095276 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2013.08.041"xsd:string |
| http://purl.uniprot.org/citations/24095276 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/24095276 | http://purl.uniprot.org/core/author | "Sun D."xsd:string |
| http://purl.uniprot.org/citations/24095276 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/24095276 | http://purl.uniprot.org/core/author | "Sweeney S.T."xsd:string |
| http://purl.uniprot.org/citations/24095276 | http://purl.uniprot.org/core/author | "Gao F.B."xsd:string |
| http://purl.uniprot.org/citations/24095276 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24095276 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/24095276 | http://purl.uniprot.org/core/pages | "264-271"xsd:string |
| http://purl.uniprot.org/citations/24095276 | http://purl.uniprot.org/core/title | "Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation."xsd:string |
| http://purl.uniprot.org/citations/24095276 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/24095276 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24095276 |
| http://purl.uniprot.org/citations/24095276 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24095276 |
| http://purl.uniprot.org/uniprot/Q9H444#attribution-C7E448C7C4E94D8FB51C41FF6E171EE6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24095276 |
| http://purl.uniprot.org/uniprot/Q86Y82#attribution-C7E448C7C4E94D8FB51C41FF6E171EE6 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24095276 |
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| http://purl.uniprot.org/uniprot/#_B4DSZ1-mappedCitation-24095276 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24095276 |