| http://purl.uniprot.org/citations/24098976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24098976 | http://www.w3.org/2000/01/rdf-schema#comment | "The main genetic factor related to HIV-1 resistance is the CCR5-Δ32 mutation; however, the homozygous genotype is uncommon. The CCR5-Δ32 mutation along with single nucleotide polymorphisms (SNPs) in the CCR5 promoter and the CCR2-V64I mutation have been included in seven human haplogroups (HH) previously associated with resistance/susceptibility to HIV-1 infection and different rates of AIDS progression. Here, we determined the association of the CCR5 promoter SNPs, the CCR5-Δ32 mutation, CCR2-V64I SNP, and HH frequencies with resistance/susceptibility to HIV-1 infection in a cohort of HIV-1-serodiscordant couples from Colombia. Seventy HIV-1-exposed, but seronegative (HESN) individuals, 57 seropositives (SP), and 112 healthy controls (HC) were included. The CCR5-Δ32 mutation and CCR2-V64I SNP were identified by PCR, and the CCR5 promoter SNPs were evaluated by sequencing. None of the individuals exhibited a homozygous Δ32 genotype; the CCR2-I allele was more frequent in HESN (34%) than HC (23%) (p=0.039, OR=1.672). The frequency of the 29G allele was higher in SP than HC (p=0.003, OR=3). HHF2 showed a higher frequency in HC (19%) than SP (9%) (p=0.027), while HHG1 was more frequent in SP (11.1%) than in HC (4.2%) (p=0.019). The AGACCAC-CCR2-I-CCR5 wild-type haplotype showed a higher frequency in SP (14.2%) than in HC (3.7%) (p=0.001). In conclusion, the CCR5-Δ32 allele is not responsible for HIV-1 resistance in this HESN group; however, the CCR2-I allele could be protective, while the 29G allele might increase the likelihood of acquiring HIV-1 infection. HHG1 and the AGACCAC-CCR2-I-CCR5 wild-type haplotype might promote HIV-1 infection while HHF2 might be related to resistance. However, additional studies are required to evaluate the implications of these findings."xsd:string |
| http://purl.uniprot.org/citations/24098976 | http://purl.org/dc/terms/identifier | "doi:10.1089/aid.2012.0299"xsd:string |
| http://purl.uniprot.org/citations/24098976 | http://purl.uniprot.org/core/author | "Pineda-Trujillo N."xsd:string |
| http://purl.uniprot.org/citations/24098976 | http://purl.uniprot.org/core/author | "Rugeles M.T."xsd:string |
| http://purl.uniprot.org/citations/24098976 | http://purl.uniprot.org/core/author | "Rojas W."xsd:string |
| http://purl.uniprot.org/citations/24098976 | http://purl.uniprot.org/core/author | "Aguilar-Jimenez W."xsd:string |
| http://purl.uniprot.org/citations/24098976 | http://purl.uniprot.org/core/author | "Zapata W."xsd:string |
| http://purl.uniprot.org/citations/24098976 | http://purl.uniprot.org/core/author | "Estrada H."xsd:string |
| http://purl.uniprot.org/citations/24098976 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24098976 | http://purl.uniprot.org/core/name | "AIDS Res Hum Retroviruses"xsd:string |
| http://purl.uniprot.org/citations/24098976 | http://purl.uniprot.org/core/pages | "1594-1603"xsd:string |
| http://purl.uniprot.org/citations/24098976 | http://purl.uniprot.org/core/title | "Influence of CCR5 and CCR2 genetic variants in the resistance/susceptibility to HIV in serodiscordant couples from Colombia."xsd:string |
| http://purl.uniprot.org/citations/24098976 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/24098976 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24098976 |
| http://purl.uniprot.org/citations/24098976 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24098976 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S6-mappedCitation-24098976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24098976 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S9-mappedCitation-24098976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24098976 |
| http://purl.uniprot.org/uniprot/#_A0A089G7F7-mappedCitation-24098976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24098976 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G0-mappedCitation-24098976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24098976 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G7-mappedCitation-24098976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24098976 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G9-mappedCitation-24098976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24098976 |
| http://purl.uniprot.org/uniprot/#_A0A089G3J8-mappedCitation-24098976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24098976 |
| http://purl.uniprot.org/uniprot/#_A0A089G3N4-mappedCitation-24098976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24098976 |
| http://purl.uniprot.org/uniprot/#_A0A089G3P0-mappedCitation-24098976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24098976 |