| http://purl.uniprot.org/citations/24101672 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24101672 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphodiesterase 10A (PDE10A) is a novel therapeutic target for the treatment of schizophrenia. Here we report a novel role of PDE10A in the regulation of caloric intake and energy homeostasis. PDE10A-deficient mice are resistant to diet-induced obesity (DIO) and associated metabolic disturbances. Inhibition of weight gain is due to hypophagia after mice are fed a highly palatable diet rich in fats and sugar but not a standard diet. PDE10A deficiency produces a decrease in caloric intake without affecting meal frequency, daytime versus nighttime feeding behavior, or locomotor activity. We tested THPP-6, a small molecule PDE10A inhibitor, in DIO mice. THPP-6 treatment resulted in decreased food intake, body weight loss, and reduced adiposity at doses that produced antipsychotic efficacy in behavioral models. We show that PDE10A inhibition increased whole-body energy expenditure in DIO mice fed a Western-style diet, achieving weight loss and reducing adiposity beyond the extent seen with food restriction alone. Therefore, chronic THPP-6 treatment conferred improved insulin sensitivity and reversed hyperinsulinemia. These data demonstrate that PDE10A inhibition represents a novel antipsychotic target that may have additional metabolic benefits over current medications for schizophrenia by suppressing food intake, alleviating weight gain, and reducing the risk for the development of diabetes."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.org/dc/terms/identifier | "doi:10.2337/db13-0247"xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Pan Y."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Smith S.M."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Cox C.D."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Hwa J."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Henry M."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Smith K.M."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Renger J.J."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Rodriguez C.G."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Keohane C.A."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Toolan D.M."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Forrest G."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Szeto D."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Nawrocki A.R."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Price O."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/author | "Raheem I.T."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/pages | "300-311"xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/title | "Genetic deletion and pharmacological inhibition of phosphodiesterase 10A protects mice from diet-induced obesity and insulin resistance."xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/24101672 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24101672 |
| http://purl.uniprot.org/citations/24101672 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24101672 |