| http://purl.uniprot.org/citations/24101674 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24101674 | http://www.w3.org/2000/01/rdf-schema#comment | "Most genetic variants associated with type 2 diabetes mellitus (T2DM) have been identified through genome-wide association studies (GWASs) in Europeans. The current study reports a GWAS for young-onset T2DM in American Indians. Participants were selected from a longitudinal study conducted in Pima Indians and included 278 cases with diabetes with onset before 25 years of age, 295 nondiabetic controls ≥45 years of age, and 267 siblings of cases or controls. Individuals were genotyped on a ∼1M single nucleotide polymorphism (SNP) array, resulting in 453,654 SNPs with minor allele frequency >0.05. SNPs were analyzed for association in cases and controls, and a family-based association test was conducted. Tag SNPs (n = 311) were selected for 499 SNPs associated with diabetes (P < 0.0005 in case-control analyses or P < 0.0003 in family-based analyses), and these SNPs were genotyped in up to 6,834 additional Pima Indians to assess replication. Rs1861612 in DNER was associated with T2DM (odds ratio = 1.29 per copy of the T allele; P = 6.6 × 10(-8), which represents genome-wide significance accounting for the number of effectively independent SNPs analyzed). Transfection studies in murine pancreatic β-cells suggested that DNER regulates expression of notch signaling pathway genes. These studies implicate DNER as a susceptibility gene for T2DM in American Indians."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.org/dc/terms/identifier | "doi:10.2337/db13-0416"xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Huang K."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Nelson R.G."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Guo T."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Bogardus C."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Ossowski V."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Baier L.J."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Bian L."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Sutherland J."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Bennett P.H."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Knowler W.C."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Weil E.J."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Hanson R.L."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Muller Y.L."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Wiedrich C."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Kobes S."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Traurig M."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Wiedrich K."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Abdussamad M."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/author | "Mahkee D."xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/24101674 | http://purl.uniprot.org/core/pages | "369-376"xsd:string |