| http://purl.uniprot.org/citations/24103557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24103557 | http://www.w3.org/2000/01/rdf-schema#comment | "Propionibacterium acnes has been implicated as one of the suggested causative antigens for sarcoidosis, a systemic granulomatous disease. By injecting heat-killed P. acnes into the dorsal skin of C57BL/6J mice on days 1, 3, 5, and 14, sarcoid-like granulomatosis was induced in skin and lungs of these mice on day 28. To clarify the role of cell adhesion molecules in cutaneous sarcoidosis, we induced sarcoid-like granulomatosis in mice deficient of intercellular adhesion molecule (ICAM)-1, L-selectin, P-selectin, or E-selectin via repeated P. acnes injection. Histopathologic analysis revealed that granuloma formation was aggravated in the skin and lungs of ICAM-1-deficient mice compared with wild-type mice. Within skin granulomas of ICAM-1-deficient mice, P. acnes immunization up-regulated mRNA expression of tumor necrosis factor-α, although it failed to induce IL-10 mRNA expression in contrast to wild-type mice. Infiltration of regulatory T cells into skin granuloma was similar between wild-type mice and ICAM-1-deficient mice. P. acnes immunization induced IL-10 production by CD4(+)CD25(+)Foxp3(+) regulatory T cells in lymph nodes of wild-type mice in vivo, which was absent in regulatory T cells of ICAM-1-deficient mice. Our results indicate that ICAM-1 is imperative for inducing regulatory T cells to produce IL-10 in vivo, which would prevent granuloma formation."xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ajpath.2013.08.021"xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/author | "Asano Y."xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/author | "Shibata S."xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/author | "Mitsui A."xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/author | "Kamata M."xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/author | "Tada Y."xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/author | "Kadono T."xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/author | "Sugaya M."xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/author | "Miyagaki T."xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/pages | "1731-1739"xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/title | "ICAM-1 deficiency exacerbates sarcoid-like granulomatosis induced by Propionibacterium acnes through impaired IL-10 production by regulatory T cells."xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://purl.uniprot.org/core/volume | "183"xsd:string |
| http://purl.uniprot.org/citations/24103557 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24103557 |
| http://purl.uniprot.org/citations/24103557 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24103557 |
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| http://purl.uniprot.org/uniprot/#_B1B507-mappedCitation-24103557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24103557 |
| http://purl.uniprot.org/uniprot/#_P13597-mappedCitation-24103557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24103557 |
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