| http://purl.uniprot.org/citations/24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24105809 | http://www.w3.org/2000/01/rdf-schema#comment | "Poly-N-acetyllactosamine (PLN) is a unique glycan composed of repeating units of the common disaccharide (Galβ1,4-GlcNAcβ1,3)n . The expression of PLN on glycoprotein core structures minimally requires enzyme activities for β1,4-galactosyltransferase (β4GalT) and β1,3-N-acetylglucosminyltransferase (β3GnT). Because β4GalTs are ubiquitous in most cells, PLN expression is generally ascribed to the tissue-specific transcription of eight known β3GnT genes in mice. In the olfactory epithelium (OE), β3GnT2 regulates expression of extended PLN chains that are essential for axon guidance and neuronal survival. N-glycan branching and core composition, however, can also modulate the extent of PLN modification. Here, we show for the first time that the β1,6-branching glycosyltransferase GCNT2 (formerly known as IGnT) is expressed at high levels specifically in the OE and other sensory ganglia. Postnatally, GCNT2 is maintained in mature olfactory neurons that co-express β3GnT2 and PLN. This highly specific co-expression suggests that GCNT2 and β3GnT2 function cooperatively in PLN synthesis. In support of this, β3GnT2 and GCNT2 co-transfection in HEK293T cells results in high levels of PLN expression on the cell surface and on adenylyl cyclase 3, a major carrier of PLN glycans in the OE. These data clearly suggest that GCNT2 functions in vivo together with β3GnT2 to determine PLN levels in olfactory neurons by regulating β1,6-branches that promote PLN extension."xsd:string |
| http://purl.uniprot.org/citations/24105809 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.24467"xsd:string |
| http://purl.uniprot.org/citations/24105809 | http://purl.uniprot.org/core/author | "Henion T.R."xsd:string |
| http://purl.uniprot.org/citations/24105809 | http://purl.uniprot.org/core/author | "Schwarting G.A."xsd:string |
| http://purl.uniprot.org/citations/24105809 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24105809 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/24105809 | http://purl.uniprot.org/core/pages | "471-478"xsd:string |
| http://purl.uniprot.org/citations/24105809 | http://purl.uniprot.org/core/title | "N-linked polylactosamine glycan synthesis is regulated by co-expression of beta3GnT2 and GCNT2."xsd:string |
| http://purl.uniprot.org/citations/24105809 | http://purl.uniprot.org/core/volume | "229"xsd:string |
| http://purl.uniprot.org/citations/24105809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24105809 |
| http://purl.uniprot.org/citations/24105809 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24105809 |
| http://purl.uniprot.org/uniprot/#_A0A286YDC7-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |
| http://purl.uniprot.org/uniprot/#_A2IQH4-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |
| http://purl.uniprot.org/uniprot/#_A2IQH5-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |
| http://purl.uniprot.org/uniprot/#_G3UWI7-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |
| http://purl.uniprot.org/uniprot/#_F7BPB5-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |
| http://purl.uniprot.org/uniprot/#_Q059T5-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |
| http://purl.uniprot.org/uniprot/#_Q3UJ01-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |
| http://purl.uniprot.org/uniprot/#_Q765H6-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |
| http://purl.uniprot.org/uniprot/#_P97402-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |
| http://purl.uniprot.org/uniprot/#_Q3TFF2-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |
| http://purl.uniprot.org/uniprot/#_Q3TVJ9-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |
| http://purl.uniprot.org/uniprot/#_Q7TPQ8-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |
| http://purl.uniprot.org/uniprot/#_Q8BW63-mappedCitation-24105809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24105809 |