| http://purl.uniprot.org/citations/24111946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24111946 | http://www.w3.org/2000/01/rdf-schema#comment | "Epigenetic mechanisms play important roles in brain development, orchestrating proliferation, differentiation, and morphogenesis. Lysine-Specific Demethylase 1 (LSD1 also known as KDM1A and AOF2) is a histone modifier involved in transcriptional repression, forming a stable core complex with the corepressors corepressor of REST (CoREST) and histone deacetylases (HDAC1/2). Importantly, in the mammalian CNS, neuronal LSD1-8a, an alternative splicing isoform of LSD1 including the mini-exon E8a, sets alongside LSD1 and is capable of enhancing neurite growth and morphogenesis. Here, we describe that the morphogenic properties of neuronal LSD1-8a require switching off repressive activity and this negative modulation is mediated in vivo by phosphorylation of the Thr369b residue coded by exon E8a. Three-dimensional crystal structure analysis using a phospho-mimetic mutant (Thr369bAsp), indicate that phosphorylation affects the residues surrounding the exon E8a-coded amino acids, causing a local conformational change. We suggest that phosphorylation, without affecting demethylase activity, causes in neurons CoREST and HDAC1/2 corepressors detachment from LSD1-8a and impairs neuronal LSD1-8a repressive activity. In neurons, Thr369b phosphorylation is required for morphogenic activity, converting neuronal LSD1-8a in a dominant-negative isoform, challenging LSD1-mediated transcriptional repression on target genes."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.org/dc/terms/identifier | "doi:10.1111/jnc.12457"xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/author | "Tedeschi G."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/author | "Mattevi A."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/author | "Pilotto S."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/author | "Sala C."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/author | "Maffioli E."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/author | "Battaglioli E."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/author | "Rusconi F."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/author | "Verpelli C."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/author | "Paganini L."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/author | "Tortorici M."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/author | "Heise C."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/author | "Toffolo E."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/pages | "603-616"xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/title | "Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2."xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://purl.uniprot.org/core/volume | "128"xsd:string |
| http://purl.uniprot.org/citations/24111946 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24111946 |
| http://purl.uniprot.org/citations/24111946 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24111946 |
| http://purl.uniprot.org/uniprot/#_B1WBY8-mappedCitation-24111946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24111946 |
| http://purl.uniprot.org/uniprot/#_A6HZP3-mappedCitation-24111946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24111946 |
| http://purl.uniprot.org/uniprot/#_A6KID6-mappedCitation-24111946 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24111946 |