| http://purl.uniprot.org/citations/24114838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24114838 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) (EIF2AK3) is essential for normal development and function of the insulin-secreting β-cell. Although genetic ablation of PERK in β-cells results in permanent neonatal diabetes in humans and mice, the underlying mechanisms remain unclear. Here, we used a newly developed and highly specific inhibitor of PERK to determine the immediate effects of acute ablation of PERK activity. We found that inhibition of PERK in human and rodent β-cells causes a rapid inhibition of secretagogue-stimulated subcellular Ca(2+) signaling and insulin secretion. These dysfunctions stem from alterations in store-operated Ca(2+) entry and sarcoplasmic endoplasmic reticulum Ca(2+)-ATPase activity. We also found that PERK regulates calcineurin, and pharmacological inhibition of calcineurin results in similar defects on stimulus-secretion coupling. Our findings suggest that interplay between calcineurin and PERK regulates β-cell Ca(2+) signaling and insulin secretion, and that loss of this interaction may have profound implications in insulin secretion defects associated with diabetes."xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.503664"xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://purl.uniprot.org/core/author | "Tang X."xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://purl.uniprot.org/core/author | "Roe M.W."xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://purl.uniprot.org/core/author | "Cavener D.R."xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://purl.uniprot.org/core/author | "McGrath B.C."xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://purl.uniprot.org/core/author | "Kopp R.F."xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24114838 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://purl.uniprot.org/core/pages | "33824-33836"xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://purl.uniprot.org/core/title | "Insulin secretion and Ca2+ dynamics in beta-cells are regulated by PERK (EIF2AK3) in concert with calcineurin."xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/24114838 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24114838 |
| http://purl.uniprot.org/citations/24114838 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24114838 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1Y1-mappedCitation-24114838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24114838 |
| http://purl.uniprot.org/uniprot/#_A0A6C0SHA8-mappedCitation-24114838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24114838 |
| http://purl.uniprot.org/uniprot/#_A0A6C0SHM7-mappedCitation-24114838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24114838 |
| http://purl.uniprot.org/uniprot/#_A0A804HIT4-mappedCitation-24114838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24114838 |
| http://purl.uniprot.org/uniprot/#_B3KY45-mappedCitation-24114838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24114838 |
| http://purl.uniprot.org/uniprot/#_E9QQ30-mappedCitation-24114838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24114838 |
| http://purl.uniprot.org/uniprot/#_Q7TQC8-mappedCitation-24114838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24114838 |
| http://purl.uniprot.org/uniprot/#_Q9NZJ5-mappedCitation-24114838 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24114838 |