| http://purl.uniprot.org/citations/24116027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24116027 | http://www.w3.org/2000/01/rdf-schema#comment | "During epithelialization, cell adhesions and polarity must be established to maintain tissue assemblies and separate the biological compartments in the body. However, the molecular basis of epithelial morphogenesis, in particular, a role of cell adhesion molecules in epithelial differentiation from stem cells, remains unclear. Here, we show that the stable and conditional expression of a tight-junction protein, claudin-6 (Cldn6), triggers epithelial morphogenesis in mouse F9 stem cells. We also demonstrate that Cldn6 induces the expression of other tight-junction and microvillus molecules including Cldn7, occludin, ZO-1α+, and ezrin/radixin/moesin-binding phosphoprotein50. These events were inhibited by attenuation of Cldn6 using RNA interference or the C-terminal half of Clostridium Perfringens enterotoxin. Furthermore, similar results were obtained in mouse embryonic stem cells. Thus, we have uncovered that the Cldn6 functions as a novel cue to induce epithelial differentiation."xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0075106"xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/author | "Sugimoto K."xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/author | "Chiba H."xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/author | "Kanai R."xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/author | "Sawada N."xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/author | "Akashi Y."xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/author | "Satohisa S."xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/author | "Ichikawa-Tomikawa N."xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/pages | "e75106"xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/title | "The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells."xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/24116027 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24116027 |
| http://purl.uniprot.org/citations/24116027 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24116027 |
| http://purl.uniprot.org/uniprot/#_Q0GH64-mappedCitation-24116027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24116027 |
| http://purl.uniprot.org/uniprot/#_Q810I9-mappedCitation-24116027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24116027 |
| http://purl.uniprot.org/uniprot/#_Q9Z262-mappedCitation-24116027 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24116027 |
| http://purl.uniprot.org/uniprot/Q0GH64 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24116027 |
| http://purl.uniprot.org/uniprot/Q9Z262 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24116027 |
| http://purl.uniprot.org/uniprot/Q810I9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24116027 |