| http://purl.uniprot.org/citations/24123680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24123680 | http://www.w3.org/2000/01/rdf-schema#comment | "The invariant NKT (iNKT) cells represent a unique group of αβ T cells that have been classified based on their exclusive usage of the invariant Vα14Jα18 TCRα-chain and their innate-like effector function. Thus far, the transcriptional programs that control Vα14Jα18 TCRα rearrangements and the population size of iNKT cells are still incompletely defined. E protein transcription factors have been shown to play necessary roles in the development of multiple T cell lineages, including iNKT cells. In this study, we examined E protein functions in T cell development through combined deletion of genes encoding E protein inhibitors Id2 and Id3. Deletion of Id2 and Id3 in T cell progenitors resulted in a partial block at the pre-TCR selection checkpoint and a dramatic increase in numbers of iNKT cells. The increase in iNKT cells is accompanied with a biased rearrangement involving Vα14 to Jα18 recombination at the double-positive stage and enhanced proliferation of iNKT cells. We further demonstrate that a 50% reduction of E proteins can cause a dramatic switch from iNKT to innate-like γδ T cell fate in Id2- and Id3-deficient mice. Collectively, these findings suggest that Id2- and Id3-mediated inhibition of E proteins controls iNKT development by restricting lineage choice and population expansion."xsd:string |
| http://purl.uniprot.org/citations/24123680 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1301252"xsd:string |
| http://purl.uniprot.org/citations/24123680 | http://purl.uniprot.org/core/author | "Jiang N."xsd:string |
| http://purl.uniprot.org/citations/24123680 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/24123680 | http://purl.uniprot.org/core/author | "Wu D."xsd:string |
| http://purl.uniprot.org/citations/24123680 | http://purl.uniprot.org/core/author | "Zhuang Y."xsd:string |
| http://purl.uniprot.org/citations/24123680 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24123680 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24123680 | http://purl.uniprot.org/core/pages | "5052-5064"xsd:string |
| http://purl.uniprot.org/citations/24123680 | http://purl.uniprot.org/core/title | "Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion."xsd:string |
| http://purl.uniprot.org/citations/24123680 | http://purl.uniprot.org/core/volume | "191"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0R4J014-mappedCitation-24123680 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24123680 |
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