| http://purl.uniprot.org/citations/24128992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24128992 | http://www.w3.org/2000/01/rdf-schema#comment | "α-Synuclein is the major component of Lewy bodies. α-Synuclein phosphorylated at Ser 129 (Phospho-α-Syn) is the most common synuclein modification observed in Parkinson's disease pathology and transgenic animal models. Polo-like kinase 2 (PLK2) was previously proposed as an important kinase in α-synuclein phosphorylation at Ser129. To better understand the role of PLK2 in α-synuclein phosphorylation in vivo, we further evaluated the effect of PLK2 genetic knockdown and pharmacological inhibition on Phospho-α-Syn levels in different brain regions of PLK2 knockout (KO), heterozygous (Het) and wild-type (WT) mice. Whereas PLK2 knockdown had no effect on Total-α-synuclein brain levels, it resulted in a gene-dosage dependent, albeit incomplete, reduction of endogenous Phospho-α-Syn levels in all brain regions investigated. No compensatory induction of other α-synuclein kinases (PLK3, casein kinase-2, G-protein-coupled receptor kinase 5 (GRK5) and GRK6) was observed at the mRNA level in the PLK2 KO mouse brain. To determine whether increased activity of another PLK family member is responsible for the residual Phospho-α-Syn levels in the PLK2 KO mouse brain, the pan-PLK inhibitor BI 2536 was tested in PLK2 KO mice. Whereas BI 2536 reduced Phospho-α-Syn levels in WT mice, it did not further reduce the residual endogenous Phospho-α-Syn levels in PLK2 KO and Het mice, suggesting that a kinase other than PLK1-3 accounts for the remaining PLK inhibitor-resistant pool in the mouse brain. Moreover, PLK3 KO in mice had no effect on both Total- and Phospho-α-Syn brain levels. These results support a significant role for a PLK kinase in phosphorylating α-synuclein at Ser129 in the brain, and suggest that PLK2 is responsible for this activity under physiological conditions."xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2013.09.061"xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/author | "Anderson J.P."xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/author | "Nelson S."xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/author | "Babcock M."xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/author | "Chiou S.S."xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/author | "Motter R."xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/author | "Bergeron M."xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/author | "Tanaka P."xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/author | "Fauss D."xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/author | "San Pablo F."xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/pages | "72-82"xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/title | "In vivo modulation of polo-like kinases supports a key role for PLK2 in Ser129 alpha-synuclein phosphorylation in mouse brain."xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://purl.uniprot.org/core/volume | "256"xsd:string |
| http://purl.uniprot.org/citations/24128992 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24128992 |
| http://purl.uniprot.org/citations/24128992 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24128992 |
| http://purl.uniprot.org/uniprot/#_F6V5S5-mappedCitation-24128992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24128992 |
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| http://purl.uniprot.org/uniprot/#_P53351-mappedCitation-24128992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24128992 |
| http://purl.uniprot.org/uniprot/#_Q3TV29-mappedCitation-24128992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24128992 |
| http://purl.uniprot.org/uniprot/#_Q60806-mappedCitation-24128992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24128992 |
| http://purl.uniprot.org/uniprot/#_Q3U0L5-mappedCitation-24128992 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24128992 |