| http://purl.uniprot.org/citations/24129709 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24129709 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokine-induced activation of signal transducer and activator of transcription 3 (STAT3) promotes the regrowth of damaged axons in the adult central nervous system (CNS). Here we show that KLF4 physically interacts with STAT3 upon cytokine-induced phosphorylation of tyrosine 705 (Y705) on STAT3. This interaction suppresses STAT3-dependent gene expression by blocking its DNA-binding activity. The deletion of KLF4 in vivo induces axon regeneration of adult retinal ganglion cells (RGCs) via Janus kinase (JAK)-STAT3 signalling. This regeneration can be greatly enhanced by exogenous cytokine treatment, or removal of an endogenous JAK-STAT3 pathway inhibitor called suppressor of cytokine signalling 3 (SOCS3). These findings reveal an unexpected cross-talk between KLF4 and activated STAT3 in the regulation of axon regeneration that might have therapeutic implications in promoting repair of injured adult CNS."xsd:string |
| http://purl.uniprot.org/citations/24129709 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms3633"xsd:string |
| http://purl.uniprot.org/citations/24129709 | http://purl.uniprot.org/core/author | "Qin S."xsd:string |
| http://purl.uniprot.org/citations/24129709 | http://purl.uniprot.org/core/author | "Zhang C.L."xsd:string |
| http://purl.uniprot.org/citations/24129709 | http://purl.uniprot.org/core/author | "Zou Y."xsd:string |
| http://purl.uniprot.org/citations/24129709 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24129709 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/24129709 | http://purl.uniprot.org/core/pages | "2633"xsd:string |
| http://purl.uniprot.org/citations/24129709 | http://purl.uniprot.org/core/title | "Cross-talk between KLF4 and STAT3 regulates axon regeneration."xsd:string |
| http://purl.uniprot.org/citations/24129709 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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