| http://purl.uniprot.org/citations/24130482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24130482 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of Type I interferon (IFN) during pathogenic HIV and SIV infections remains unclear, with conflicting observations suggesting protective versus immunopathological effects. We therefore examined the effect of IFNα/β on T cell death and viremia in HIV infection. Ex vivo analysis of eight pro- and anti-apoptotic molecules in chronic HIV-1 infection revealed that pro-apoptotic Bak was increased in CD4+ T cells and correlated directly with sensitivity to CD95/Fas-mediated apoptosis and inversely with CD4+ T cell counts. Apoptosis sensitivity and Bak expression were primarily increased in effector memory T cells. Knockdown of Bak by RNA interference inhibited CD95/Fas-induced death of T cells from HIV-1-infected individuals. In HIV-1-infected patients, IFNα-stimulated gene expression correlated positively with ex vivo T cell Bak levels, CD95/Fas-mediated apoptosis and viremia and negatively with CD4+ T cell counts. In vitro IFNα/β stimulation enhanced Bak expression, CD95/Fas expression and CD95/Fas-mediated apoptosis in healthy donor T cells and induced death of HIV-specific CD8+ T cells from HIV-1-infected patients. HIV-1 in vitro sensitized T cells to CD95/Fas-induced apoptosis and this was Toll-like receptor (TLR)7/9- and Type I IFN-dependent. This sensitization by HIV-1 was due to an indirect effect on T cells, as it occurred in peripheral blood mononuclear cell cultures but not purified CD4+ T cells. Finally, peak IFNα levels and viral loads correlated negatively during acute SIV infection suggesting a potential antiviral effect, but positively during chronic SIV infection indicating that either the virus drives IFNα production or IFNα may facilitate loss of viral control. The above findings indicate stage-specific opposing effects of Type I IFNs during HIV-1 infection and suggest a novel mechanism by which these cytokines contribute to T cell depletion, dysregulation of cellular immunity and disease progression."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1003658"xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "Yang G."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "Giavedoni L.D."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "Kathuria N."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "Jacobson J.M."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "McGettigan S.E."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "Katsikis P.D."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "Mueller Y.M."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "Lewis M.G."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "Do D.H."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "Boesteanu A.C."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "Fraietta J.A."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "Gracias D.T."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/author | "Hope J.L."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/name | "PLoS Pathog"xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/pages | "e1003658"xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/title | "Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection."xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24130482 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24130482 |
| http://purl.uniprot.org/citations/24130482 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24130482 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z319-mappedCitation-24130482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24130482 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z391-mappedCitation-24130482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24130482 |