| http://purl.uniprot.org/citations/24136904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24136904 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclic (c-di-GMP) is the prevalent intracellular signaling intermediate in bacteria. It triggers a spectrum of responses that cause bacteria to shift from a swarming motile phase to sessile biofilm formation. However, additional functions for c-di-GMP and roles for related molecules, such as c-di-AMP and c-AMP-GMP continue to be uncovered. The first usage of cyclic-di-nucleotide (c-di-NMP) signaling in the eukaryote domain emerged only recently. In dictyostelid social amoebas, c-di-GMP is a secreted signal that induces motile amoebas to differentiate into sessile stalk cells. In humans, c-di-NMPs, which are either produced endogenously in response to foreign DNA or by invading bacterial pathogens, trigger the innate immune system by activating the expression of interferon genes. STING, the human c-di-NMP receptor, is conserved throughout metazoa and their closest unicellular relatives, suggesting protist origins for human c-di-NMP signaling. Compared to the limited number of conserved protein domains that detect the second messengers cAMP and cGMP, the domains that detect the c-di-NMPs are surprisingly varied."xsd:string |
| http://purl.uniprot.org/citations/24136904 | http://purl.org/dc/terms/identifier | "doi:10.1002/iub.1212"xsd:string |
| http://purl.uniprot.org/citations/24136904 | http://purl.uniprot.org/core/author | "Schaap P."xsd:string |
| http://purl.uniprot.org/citations/24136904 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24136904 | http://purl.uniprot.org/core/name | "IUBMB Life"xsd:string |
| http://purl.uniprot.org/citations/24136904 | http://purl.uniprot.org/core/pages | "897-903"xsd:string |
| http://purl.uniprot.org/citations/24136904 | http://purl.uniprot.org/core/title | "Cyclic di-nucleotide signaling enters the eukaryote domain."xsd:string |
| http://purl.uniprot.org/citations/24136904 | http://purl.uniprot.org/core/volume | "65"xsd:string |
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