| http://purl.uniprot.org/citations/24139759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24139759 | http://www.w3.org/2000/01/rdf-schema#comment | "During embryogenesis, the Activin/Nodal pathway promotes the mesendodermal lineage and inhibits neural fate. The molecular mechanisms underlying this role of the Activin/Nodal pathway are not clear. In this study, we report a role for protein tyrosine phosphatase 1B (PTP1B) in Activin-mediated early fate decisions during ESC differentiation and show that PTP1B acts as an effector of the Activin pathway to specify mesendodermal or neural fate. We found that the Activin/ALK4 pathway directly recruits PTP1B and stimulates its release from the endoplasmic reticulum through ALK4-mediated cleavage. Subsequently, PTP1B suppresses p-ERK1/2 signaling to inhibit neural specification and promote mesendodermal commitment. These findings suggest that a noncanonical Activin signaling pathway functions in lineage specification of mouse and human embryonic stem cells."xsd:string |
| http://purl.uniprot.org/citations/24139759 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stem.2013.09.016"xsd:string |
| http://purl.uniprot.org/citations/24139759 | http://purl.uniprot.org/core/author | "Lin H.H."xsd:string |
| http://purl.uniprot.org/citations/24139759 | http://purl.uniprot.org/core/author | "Dvorak P."xsd:string |
| http://purl.uniprot.org/citations/24139759 | http://purl.uniprot.org/core/author | "Uwanogho D."xsd:string |
| http://purl.uniprot.org/citations/24139759 | http://purl.uniprot.org/core/author | "Sun Y.M."xsd:string |
| http://purl.uniprot.org/citations/24139759 | http://purl.uniprot.org/core/author | "Matulka K."xsd:string |
| http://purl.uniprot.org/citations/24139759 | http://purl.uniprot.org/core/author | "Hribkova H."xsd:string |
| http://purl.uniprot.org/citations/24139759 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24139759 | http://purl.uniprot.org/core/name | "Cell Stem Cell"xsd:string |
| http://purl.uniprot.org/citations/24139759 | http://purl.uniprot.org/core/pages | "706-719"xsd:string |
| http://purl.uniprot.org/citations/24139759 | http://purl.uniprot.org/core/title | "PTP1B is an effector of activin signaling and regulates neural specification of embryonic stem cells."xsd:string |
| http://purl.uniprot.org/citations/24139759 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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| http://purl.uniprot.org/uniprot/#_Q3UXL8-mappedCitation-24139759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24139759 |
| http://purl.uniprot.org/uniprot/#_Q3UY39-mappedCitation-24139759 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24139759 |