http://purl.uniprot.org/citations/24140063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/24140063 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-Myc oncogene is amplified in many tumor types. It is an important regulator of cell proliferation and has been linked to altered miRNA expression, suggesting that c-Myc-regulated miRNAs might contribute to tumor progression. Although miR-26a has been reported to be upregulated in glioblastoma multiforme (GBM), the mechanism has not been established. We have shown that ectopic expression of miR-26a influenced cell proliferation by targeting PTEN, a tumor suppressor gene that is inactivated in many common malignancies, including GBM. Our findings suggest that c-Myc modulates genes associated with oncogenesis in GBM through deregulation of miRNAs via the c-Myc-miR-26a-PTEN signaling pathway. This may be of clinical relevance."xsd:string |
http://purl.uniprot.org/citations/24140063 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2013.10.034"xsd:string |
http://purl.uniprot.org/citations/24140063 | http://purl.uniprot.org/core/author | "Ge J."xsd:string |
http://purl.uniprot.org/citations/24140063 | http://purl.uniprot.org/core/author | "Qiu Y."xsd:string |
http://purl.uniprot.org/citations/24140063 | http://purl.uniprot.org/core/author | "Guo P."xsd:string |
http://purl.uniprot.org/citations/24140063 | http://purl.uniprot.org/core/author | "Lan J."xsd:string |
http://purl.uniprot.org/citations/24140063 | http://purl.uniprot.org/core/author | "Nie Q."xsd:string |
http://purl.uniprot.org/citations/24140063 | http://purl.uniprot.org/core/author | "Mao Q."xsd:string |
http://purl.uniprot.org/citations/24140063 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
http://purl.uniprot.org/citations/24140063 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
http://purl.uniprot.org/citations/24140063 | http://purl.uniprot.org/core/pages | "186-190"xsd:string |
http://purl.uniprot.org/citations/24140063 | http://purl.uniprot.org/core/title | "C-Myc negatively controls the tumor suppressor PTEN by upregulating miR-26a in glioblastoma multiforme cells."xsd:string |
http://purl.uniprot.org/citations/24140063 | http://purl.uniprot.org/core/volume | "441"xsd:string |
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