| http://purl.uniprot.org/citations/24140340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24140340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24140340 | http://www.w3.org/2000/01/rdf-schema#comment | "Low-density lipoprotein receptor-related protein 4 (Lrp4) is essential for pre- and post-synaptic specialization at the neuromuscular junction (NMJ), an indispensable synapse between a motor nerve and skeletal muscle. Muscle-specific receptor tyrosine kinase MuSK must form a complex with Lrp4 to organize postsynaptic specialization at NMJs. Here, we show that the chaperon Mesdc2 binds to the intracellular form of Lrp4 and promotes its glycosylation and cell-surface expression. Furthermore, knockdown of Mesdc2 suppresses cell-surface expression of Lrp4, activation of MuSK, and postsynaptic specialization in muscle cells. These results suggest that Mesdc2 plays an essential role in NMJ formation by promoting Lrp4 maturation."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2013.10.001"xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2013.10.001"xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/author | "Yokoyama K."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/author | "Yokoyama K."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/author | "Iemura S."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/author | "Iemura S."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/author | "Natsume T."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/author | "Natsume T."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/author | "Yamanashi Y."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/author | "Yamanashi Y."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/author | "Hoshi T."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/author | "Hoshi T."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/author | "Tezuka T."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/author | "Tezuka T."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/pages | "3749-3754"xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/pages | "3749-3754"xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/title | "Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes."xsd:string |
| http://purl.uniprot.org/citations/24140340 | http://purl.uniprot.org/core/title | "Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes."xsd:string |