| http://purl.uniprot.org/citations/24140420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24140420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24140420 | http://www.w3.org/2000/01/rdf-schema#comment | "The selective degradation of intracellular components by autophagy involves sequential interactions of the cargo with a receptor, which also binds the autophagosomal protein Atg8 and a scaffold protein. Here, we demonstrated that mutations in C. elegans epg-11, which encodes an arginine methyltransferase homologous to PRMT1, cause the defective removal of PGL-1 and PGL-3 (cargo)-SEPA-1 (receptor) complexes, known as PGL granules, from somatic cells during embryogenesis. Autophagic degradation of the PGL granule scaffold protein EPG-2 and other protein aggregates was unaffected in epg-11/prmt-1 mutants. Loss of epg-11/prmt-1 activity impairs the association of PGL granules with EPG-2 and LGG-1 puncta. EPG-11/PRMT-1 directly methylates arginines in the RGG domains of PGL-1 and PGL-3. Autophagic removal of PGL proteins is impaired when the methylated arginines are mutated. Our study reveals that posttranslational arginine methylation regulates the association of the cargo-receptor complex with the scaffold protein, providing a mechanism for modulating degradation efficiency in selective autophagy."xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2013.09.014"xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2013.09.014"xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/author | "Zhang H."xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/author | "Yang P."xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/author | "Yang P."xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/author | "Tian E."xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/author | "Tian E."xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/pages | "421-433"xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/pages | "421-433"xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/title | "Arginine methylation modulates autophagic degradation of PGL granules in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/title | "Arginine methylation modulates autophagic degradation of PGL granules in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/24140420 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24140420 |
| http://purl.uniprot.org/citations/24140420 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24140420 |