| http://purl.uniprot.org/citations/24141778 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24141778 | http://www.w3.org/2000/01/rdf-schema#comment | "Oncogene MYC is highly expressed in many human cancers and functions as a global regulator of ribosome biogenesis. Previously, we reported that ribosomal protein (RP) L11 binds to c-Myc and inhibits its transcriptional activity in response to ribosomal stress. Here, we show that RPL5, co-operatively with RPL11, guides the RNA-induced silencing complex (RISC) to c-Myc mRNA and mediates the degradation of the mRNA, consequently leading to inhibition of c-Myc activity. Knocking down of RPL5 induced c-Myc expression at both mRNA and protein levels, whereas overexpression of RPL5 suppressed c-Myc expression and activity. Immunoprecipitation revealed that RPL5 binds to 3'UTR of c-Myc mRNA and two subunits of RISC, TRBP (HIV-1 TAR RNA-binding protein) and Ago2, mediating the targeting of c-Myc mRNA by miRNAs. Interestingly, RPL5 and RPL11 co-resided on c-Myc mRNA and suppressed c-Myc expression co-operatively. These findings uncover a mechanism by which these two RPs can co-operatively suppress c-Myc expression, allowing a tightly controlled ribosome biogenesis in cells."xsd:string |
| http://purl.uniprot.org/citations/24141778 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2013.430"xsd:string |
| http://purl.uniprot.org/citations/24141778 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/24141778 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/24141778 | http://purl.uniprot.org/core/author | "Gatignol A."xsd:string |
| http://purl.uniprot.org/citations/24141778 | http://purl.uniprot.org/core/author | "Liao J.M."xsd:string |
| http://purl.uniprot.org/citations/24141778 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24141778 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/24141778 | http://purl.uniprot.org/core/pages | "4916-4923"xsd:string |
| http://purl.uniprot.org/citations/24141778 | http://purl.uniprot.org/core/title | "Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex."xsd:string |
| http://purl.uniprot.org/citations/24141778 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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