http://purl.uniprot.org/citations/24142406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/24142406 | http://www.w3.org/2000/01/rdf-schema#comment | "Pyk2 and Src phosphorylation is initiated by CCL18, which promotes breast cancer metastasis via its functional G protein-coupled receptor PITPNM3. However, the function of Pyk2 and Src in CCL18-induced breast cancer metastasis is poorly understood. Quantitative reverse-transcription polymerase chain reactions (qRT-PCRs), Western blot, boyden chamber assay, and adherence assay were performed to delineate the consequences of Pyk2/Src in CCL18-induced breast cancer cells. Co-immunoprecipitation and immunofluorescence were performed to analyze the interaction of proteins. Upon the binding of CCL18 to PITPNM3, Pyk2 translocates from the cytoplasm to the plasma membrane to form a stable complex with PITPNM3, subsequently activating Src kinase. Moreover, upon stimulation with CCL18, Pyk2 and Src become essential for integrin alpha5/beta1 clustering-dependent adherence, migration, and invasion. Pyk2 and Src are important in CCL18-induced breast cancer metastasis."xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.24697"xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/author | "Wu W."xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/author | "Li H.Y."xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/author | "Chen J.Q."xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/author | "Cui X.Y."xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/author | "Yu F.Y."xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/author | "Yao H.R."xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/author | "Song E.W."xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/pages | "596-603"xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/title | "Pyk2 and Src mediate signaling to CCL18-induced breast cancer metastasis."xsd:string |
http://purl.uniprot.org/citations/24142406 | http://purl.uniprot.org/core/volume | "115"xsd:string |
http://purl.uniprot.org/citations/24142406 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24142406 |
http://purl.uniprot.org/citations/24142406 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24142406 |
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http://purl.uniprot.org/uniprot/#_P55774-mappedCitation-24142406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24142406 |
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http://purl.uniprot.org/uniprot/Q6ZRA8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24142406 |
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http://purl.uniprot.org/uniprot/Q14289 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24142406 |