| http://purl.uniprot.org/citations/24145406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24145406 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24145406 | http://www.w3.org/2000/01/rdf-schema#comment | "Excessive genome damage activates the apoptosis response. Protein kinase HIPK2 is a key regulator of DNA damage-induced apoptosis. Here, we deciphered the molecular mechanism of HIPK2 activation and show its relevance for DNA damage-induced apoptosis in cellulo and in vivo. HIPK2 autointeracts and site-specifically autophosphorylates upon DNA damage at Thr880/Ser882. Autophosphorylation regulates HIPK2 activity and mutation of the phosphorylation-acceptor sites deregulates p53 Ser46 phosphorylation and apoptosis in cellulo. Moreover, HIPK2 autophosphorylation is conserved between human and zebrafish and is important for DNA damage-induced apoptosis in vivo. Mechanistically, autophosphorylation creates a binding signal for the phospho-specific isomerase Pin1. Pin1 links HIPK2 activation to its stabilization by inhibiting HIPK2 polyubiquitination and modulating Siah-1-HIPK2 interaction. Concordantly, Pin1 is required for DNA damage-induced HIPK2 stabilization and p53 Ser46 phosphorylation and is essential for induction of apotosis both in cellulo and in zebrafish. Our results identify an evolutionary conserved mechanism regulating DNA damage-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1310001110"xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Conrad E."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Conrad E."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Mantovani F."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Mantovani F."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Hofmann T.G."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Hofmann T.G."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Peri F."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Peri F."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "del Sal G."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "del Sal G."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Bitomsky N."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Bitomsky N."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Sombroek D."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Sombroek D."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Moritz C."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Moritz C."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Glas C."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Glas C."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Greiner V."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Greiner V."xsd:string |
| http://purl.uniprot.org/citations/24145406 | http://purl.uniprot.org/core/author | "Herbel C."xsd:string |