| http://purl.uniprot.org/citations/24153184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24153184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24153184 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein biosynthesis depends on the availability of ribosomes, which in turn relies on ribosomal RNA production. In eukaryotes, this process is carried out by RNA polymerase I (Pol I), a 14-subunit enzyme, the activity of which is a major determinant of cell growth. Here we present the crystal structure of Pol I from Saccharomyces cerevisiae at 3.0 Å resolution. The Pol I structure shows a compact core with a wide DNA-binding cleft and a tightly anchored stalk. An extended loop mimics the DNA backbone in the cleft and may be involved in regulating Pol I transcription. Subunit A12.2 extends from the A190 jaw to the active site and inserts a transcription elongation factor TFIIS-like zinc ribbon into the nucleotide triphosphate entry pore, providing insight into the role of A12.2 in RNA cleavage and Pol I insensitivity to α-amanitin. The A49-A34.5 heterodimer embraces subunit A135 through extended arms, thereby contacting and potentially regulating subunit A12.2."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature12636"xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature12636"xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Legrand P."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Legrand P."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Muller C.W."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Muller C.W."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Taylor N.M."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Taylor N.M."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Rashid U.J."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Rashid U.J."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Ruiz F.M."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Ruiz F.M."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Steuerwald U."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Steuerwald U."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Fernandez-Tornero C."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Fernandez-Tornero C."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Gruene T."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Gruene T."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Moreno-Morcillo M."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/author | "Moreno-Morcillo M."xsd:string |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24153184 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |