| http://purl.uniprot.org/citations/24155177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24155177 | http://www.w3.org/2000/01/rdf-schema#comment | "The prognosis of patients undergoing hematopoietic stem cell transplantation (HSCT) depends on the rapid recovery and sustained life-long hematopoiesis. The activation of the fibrinolytic pathway promotes hematopoietic regeneration; however, the role of plasminogen activator inhibitor-1 (PAI-1), a negative regulator of the fibrinolytic pathway, has not yet been elucidated. We herein demonstrate that bone marrow (BM) stromal cells, especially osteoblasts, produce PAI-1 in response to myeloablation, which negatively regulates the hematopoietic regeneration in the BM microenvironment. Total body irradiation in mice dramatically increased the local expression levels of fibrinolytic factors, including tissue-type plasminogen activator (tPA), plasmin, and PAI-1. Genetic disruption of the PAI-1 gene, or pharmacological inhibition of PAI-1 activity, significantly improved the myeloablation-related mortality and promoted rapid hematopoietic recovery after HSCT through the induction of hematopoiesis-promoting factors. The ability of a PAI-1 inhibitor to enhance hematopoietic regeneration was abolished when tPA-deficient mice were used as recipients, thus indicating that PAI-1 represses tPA-dependent hematopoietic regeneration. The PAI-1 inhibitor not only accelerated the expansion of the donor HSCs during the early-stage of regeneration, but also supported long-term hematopoiesis. Our results indicate that the inhibition of PAI-1 activity could be a therapeutic approach to facilitate the rapid recovery and sustained hematopoiesis after HSCT."xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://purl.org/dc/terms/identifier | "doi:10.1002/stem.1577"xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://purl.uniprot.org/core/author | "Miyata T."xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://purl.uniprot.org/core/author | "Ando K."xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://purl.uniprot.org/core/author | "Yahata T."xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://purl.uniprot.org/core/author | "Onizuka M."xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://purl.uniprot.org/core/author | "Ibrahim A.A."xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://purl.uniprot.org/core/author | "Dan T."xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://purl.uniprot.org/core/author | "Van Ypersele De Strihou C."xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24155177 | http://purl.uniprot.org/core/name | "Stem Cells"xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://purl.uniprot.org/core/pages | "946-958"xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://purl.uniprot.org/core/title | "Inhibition of plasminogen activator inhibitor type-1 activity enhances rapid and sustainable hematopoietic regeneration."xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/24155177 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24155177 |
| http://purl.uniprot.org/citations/24155177 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24155177 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ70-mappedCitation-24155177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24155177 |
| http://purl.uniprot.org/uniprot/#_A0A087WQM1-mappedCitation-24155177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24155177 |
| http://purl.uniprot.org/uniprot/#_P11214-mappedCitation-24155177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24155177 |
| http://purl.uniprot.org/uniprot/#_D0ESZ5-mappedCitation-24155177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24155177 |
| http://purl.uniprot.org/uniprot/#_D0ESZ6-mappedCitation-24155177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24155177 |
| http://purl.uniprot.org/uniprot/#_G5E899-mappedCitation-24155177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24155177 |
| http://purl.uniprot.org/uniprot/#_Q7TPE9-mappedCitation-24155177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24155177 |
| http://purl.uniprot.org/uniprot/#_P22777-mappedCitation-24155177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24155177 |