| http://purl.uniprot.org/citations/24155921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24155921 | http://www.w3.org/2000/01/rdf-schema#comment | "Forkhead Box P3 (FOXP3) is a member of the forkhead/winged helix family of the transcription factors and plays an important role not only as a master gene in T-regulatory cells, but also as a tumor suppressor. In this study, we identified lymphocyte-specific protein tyrosine kinase (LCK), which correlates with cancer malignancy, as a binding partner of FOXP3. FOXP3 downregulated LCK-induced MMP9, SKP2, and VEGF-A expression. We observed that LCK phosphorylated Tyr-342 of FOXP3 by immunoprecipitation and in vitro kinase assay, and the replacement of Tyr-342 with phenylalanine (Y342F) abolished the ability to suppress MMP9 expression. Although FOXP3 decreased the invasive ability induced by LCK in MCF-7 cells, Y342F mutation in FOXP3 diminished this suppressive effect. Thus we demonstrate for the first time that LCK upregulates FOXP3 by tyrosine phosphorylation, resulting in decreased MMP9, SKP2, and VEGF-A expression, and suppressed cellular invasion. We consider that further clarification of transcriptional mechanism of FOXP3 may facilitate the development of novel therapeutic approaches to suppress cancer malignancy."xsd:string |
| http://purl.uniprot.org/citations/24155921 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0077099"xsd:string |
| http://purl.uniprot.org/citations/24155921 | http://purl.uniprot.org/core/author | "Morita A."xsd:string |
| http://purl.uniprot.org/citations/24155921 | http://purl.uniprot.org/core/author | "Kim N.S."xsd:string |
| http://purl.uniprot.org/citations/24155921 | http://purl.uniprot.org/core/author | "Nakahira K."xsd:string |
| http://purl.uniprot.org/citations/24155921 | http://purl.uniprot.org/core/author | "Yanagihara I."xsd:string |
| http://purl.uniprot.org/citations/24155921 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24155921 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24155921 | http://purl.uniprot.org/core/pages | "e77099"xsd:string |
| http://purl.uniprot.org/citations/24155921 | http://purl.uniprot.org/core/title | "Phosphorylation of FOXP3 by LCK downregulates MMP9 expression and represses cell invasion."xsd:string |
| http://purl.uniprot.org/citations/24155921 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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