| http://purl.uniprot.org/citations/24157462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24157462 | http://www.w3.org/2000/01/rdf-schema#comment | "Acne vulgaris is potentially a severe skin disease associated with colonization of the pilo-sebaceous unit by the commensal bacterium Propionibacterium acnes and inflammation. P. acnes is considered to contribute to inflammation in acne, but the pathways involved are unclear. Here we reveal a mechanism that regulates inflammatory responses to P. acnes. We show that IL-1β mRNA and the active processed form of IL-1β are abundant in inflammatory acne lesions. Moreover, we identify P. acnes as a trigger of monocyte-macrophage NLRP3-inflammasome activation, IL-1β processing and secretion that is dependent on phagocytosis, lysosomal destabilization, reactive oxygen species, and cellular K+ efflux. In mice, inflammation induced by P. acnes is critically dependent on IL-1β and the NLRP3 inflammasome of myeloid cells. These findings show that the commensal P. acnes-by activating the inflammasome-can trigger an innate immune response in the skin, thus establishing the NLRP3-inflammasome and IL-1β as possible therapeutic targets in acne."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.org/dc/terms/identifier | "doi:10.1038/jid.2013.438"xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "Kolios A."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "French L.E."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "Kistowska M."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "Feldmeyer L."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "Jankovic D."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "Contassot E."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "Fenini G."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "Gehrke S."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "Navarini A."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "Schauber J."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "Ganceviciene R."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "Kerl K."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/author | "Fettelschoss A."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/pages | "677-685"xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/title | "IL-1beta drives inflammatory responses to propionibacterium acnes in vitro and in vivo."xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://purl.uniprot.org/core/volume | "134"xsd:string |
| http://purl.uniprot.org/citations/24157462 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24157462 |
| http://purl.uniprot.org/citations/24157462 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24157462 |
| http://purl.uniprot.org/uniprot/#_A0A510GAG5-mappedCitation-24157462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24157462 |
| http://purl.uniprot.org/uniprot/#_A0A571BDI1-mappedCitation-24157462 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24157462 |