| http://purl.uniprot.org/citations/24157794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24157794 | http://www.w3.org/2000/01/rdf-schema#comment | "New findings show that neurotrophic and antidepressant effects of 5-HT in brain can, in part, be mediated by activation of the 5-HT1A receptor protomer in the hippocampal and raphe FGFR1-5-HT1A heteroreceptor complexes enhancing the FGFR1 signaling. The dynamic agonist modulation of the FGFR1-5-HT1A heteroreceptor complexes and their recruitment of β-arrestin is now determined in cellular models with focus on its impact on 5-HT1AR and FGFR1 homodimerization in the heteroreceptor complexes based on BRET(2) assays. The findings show that coagonist treatment with 8-OH-DPAT and FGF2 but not treatment with the 5-HT1A agonist alone markedly increases the BRETmax values and significantly reduces the BRET50 values of 5HT1A homodimerization. The effects of FGF2 or FGF20 with or without the 5-HT1A agonist were also studied on the FGFR1 homodimerization of the heteroreceptor complexes. FGF2 produced a marked and rapid increase in FGFR1 homodimerization which partially declined over a 10min period. Cotreatment with FGF2 and 5-HT1A agonist blocked this decline in FGFR1 homodimerization. Furthermore, FGF2 alone produced a small increase in the BRET(2) signal from the 5-HT1A-β-arrestin2 receptor-protein complex which was additive to the marked effect of 8-OH-DPAT alone. Taken together, the participation of 5-HT1A and FGFR1 homodimers and recruitment of β-arrestin2 was demonstrated in the FGFR1-5-HT1A heteroreceptor complexes upon agonist treatments."xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2013.10.067"xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://purl.uniprot.org/core/author | "Borroto-Escuela D.O."xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://purl.uniprot.org/core/author | "Fuxe K."xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://purl.uniprot.org/core/author | "Palkovits M."xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://purl.uniprot.org/core/author | "Agnati L.F."xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://purl.uniprot.org/core/author | "Corrales F."xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://purl.uniprot.org/core/author | "Narvaez M."xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://purl.uniprot.org/core/author | "Oflijan J."xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24157794 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://purl.uniprot.org/core/pages | "387-392"xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://purl.uniprot.org/core/title | "Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of beta-arrestin2."xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://purl.uniprot.org/core/volume | "441"xsd:string |
| http://purl.uniprot.org/citations/24157794 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24157794 |
| http://purl.uniprot.org/citations/24157794 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24157794 |
| http://purl.uniprot.org/uniprot/P08908#attribution-C09A4677ECEC6A1E50346A8292B4F176 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24157794 |
| http://purl.uniprot.org/uniprot/Q9NP95#attribution-C09A4677ECEC6A1E50346A8292B4F176 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24157794 |
| http://purl.uniprot.org/uniprot/P11362#attribution-C09A4677ECEC6A1E50346A8292B4F176 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24157794 |
| http://purl.uniprot.org/uniprot/P09038#attribution-C09A4677ECEC6A1E50346A8292B4F176 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24157794 |
| http://purl.uniprot.org/uniprot/#_A0N5V3-mappedCitation-24157794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24157794 |
| http://purl.uniprot.org/uniprot/#_A8K4I6-mappedCitation-24157794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24157794 |
| http://purl.uniprot.org/uniprot/#_A8K5W4-mappedCitation-24157794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24157794 |
| http://purl.uniprot.org/uniprot/#_Q5ZGX3-mappedCitation-24157794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24157794 |