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| http://purl.uniprot.org/citations/24161943 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuron navigator 2 (NAV2) is required for all-trans retinoic acid (atRA) to induce neurite outgrowth in human neuroblastoma cells. Further, ectopic overexpression of full-length human NAV2 rescues an axonal elongation defect in the Caenorhabditis elegans unc-53 (NAV2 ortholog) mutant. Using a region of NAV2 that independently associates with the cytoskeleton as bait in a yeast-two-hybrid screen, 14-3-3ε was identified as a novel NAV2 interacting partner. Amino acids 761-960 of NAV2 are sufficient to confer a positive interaction with 14-3-3ε as evidenced by a two-hybrid screen and co-immunoprecipitation assay. Knockdown of 14-3-3ε leads to a decrease in atRA-mediated neurite outgrowth, similar to the elongation defects observed when NAV2 is depleted or mutated. Likewise, posterior lateral microtubule (PLM) defects in C. elegans fed unc-53 RNAi are similar to those fed ftt-2 (14-3-3 homolog) RNAi. The discovery of an interaction between NAV2 and 14-3-3ε could provide insight into the mechanism by which NAV2 participates in promoting cell migration and neuronal elongation."xsd:string |
| http://purl.uniprot.org/citations/24161943 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.abb.2013.10.012"xsd:string |
| http://purl.uniprot.org/citations/24161943 | http://purl.uniprot.org/core/author | "Clagett-Dame M."xsd:string |
| http://purl.uniprot.org/citations/24161943 | http://purl.uniprot.org/core/author | "Marzinke M.A."xsd:string |
| http://purl.uniprot.org/citations/24161943 | http://purl.uniprot.org/core/author | "Duratinsky J."xsd:string |
| http://purl.uniprot.org/citations/24161943 | http://purl.uniprot.org/core/author | "Mavencamp T."xsd:string |
| http://purl.uniprot.org/citations/24161943 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24161943 | http://purl.uniprot.org/core/name | "Arch Biochem Biophys"xsd:string |
| http://purl.uniprot.org/citations/24161943 | http://purl.uniprot.org/core/pages | "94-100"xsd:string |
| http://purl.uniprot.org/citations/24161943 | http://purl.uniprot.org/core/title | "14-3-3epsilon and NAV2 interact to regulate neurite outgrowth and axon elongation."xsd:string |
| http://purl.uniprot.org/citations/24161943 | http://purl.uniprot.org/core/volume | "540"xsd:string |
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