| http://purl.uniprot.org/citations/24162658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24162658 | http://www.w3.org/2000/01/rdf-schema#comment | "The TNF-JNK pathway is a highly conserved signaling pathway that regulates a wide spectrum of biological processes including cell death and migration. To further delineate this pathway, we carried out a genetic screen for dominant modifiers of the cell death phenotype triggered by ectopic expression of Eiger (Egr), the Drosophila TNF ortholog. Here we show that Bendless (Ben), an E2 ubiquitin-conjugating enzyme, modulates Egr-induced JNK activation and cell death through dTRAF2. Furthermore, Ben physically interacts with dTRAF2 and regulates Egr-induced dTRAF2 polyubiquitination. Finally, Ben is required for JNK-dependent tumor progression, cell migration, oxidative stress resistance and longevity. Our results indicate that Ben constitutes an essential component of the evolutionarily conserved TNF-JNK pathway that modulates cell death and invasion, tumor progression, stress response and lifespan in metazoans."xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2013.154"xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://purl.uniprot.org/core/author | "Ma X."xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://purl.uniprot.org/core/author | "Xu T."xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://purl.uniprot.org/core/author | "Xue L."xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24162658 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://purl.uniprot.org/core/pages | "407-415"xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://purl.uniprot.org/core/title | "Bendless modulates JNK-mediated cell death and migration in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/24162658 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24162658 |
| http://purl.uniprot.org/citations/24162658 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24162658 |
| http://purl.uniprot.org/uniprot/Q8MUJ1#attribution-FB4BC31C3EBEBDC03CE664856F3EE6E7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24162658 |
| http://purl.uniprot.org/uniprot/Q23977#attribution-FB4BC31C3EBEBDC03CE664856F3EE6E7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24162658 |
| http://purl.uniprot.org/uniprot/Q9V3Q6#attribution-FB4BC31C3EBEBDC03CE664856F3EE6E7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24162658 |
| http://purl.uniprot.org/uniprot/P35128#attribution-83CC54A4898E8ABEA9D839B18C4A7D06 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24162658 |
| http://purl.uniprot.org/uniprot/P35128#attribution-FB4BC31C3EBEBDC03CE664856F3EE6E7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24162658 |
| http://purl.uniprot.org/uniprot/Q9W3I9#attribution-FB4BC31C3EBEBDC03CE664856F3EE6E7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24162658 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHN3-mappedCitation-24162658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24162658 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHY2-mappedCitation-24162658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24162658 |