| http://purl.uniprot.org/citations/24163288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24163288 | http://www.w3.org/2000/01/rdf-schema#comment | "Cancerous inhibitor of PP2A (protein phosphatase 2A) (CIP2A) is an inhibitor of PP2A, a phosphatase and tumor suppressor that regulates cell proliferation, differentiation, and survival. The aim of this study was to investigate whether CIP2A plays a role in the progression of myelodysplastic syndromes (MDS). Immunohistochemical analysis revealed that a fraction patients having refractory anemia with excess blasts (RAEB)-1 (4 out of 12) and RAEB-2 (10 out of 14) exhibited significant expression of CIP2A in bone marrow hematopoietic cells, while all patients with refractory cytopenia with unilineage or multilineage dysplasia (RCUD/RCMD) (0 out of 18) and the control group (0 out of 17) were negative. CIP2A was mainly expressed by the MPO-positive myeloid series of cells and partly by the CD34-positive cells in association with the expression of phosphorylated c-MYC (p-c-MYC) protein and the cell cycle-related proteins Ki-67, MCM2, and geminin. The percentage of p-c-MYC-positive cells in the bone marrow of CIP2A-positive MDS cases was significantly higher than that in CIP2A-negative MDS cases (P < 0.01). The expression levels of mRNA for CIP2A and PP2A exhibited positive correlation in MDS/control bone marrow. These results suggest that up-regulated expression of CIP2A might play a role in the proliferation of blasts in the MDS bone marrow and in disease progression in at least some cases."xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12253-013-9709-y"xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/author | "Kitagawa M."xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/author | "Abe S."xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/author | "Hidaka M."xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/author | "Kurata M."xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/author | "Murayama T."xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/author | "Kawano F."xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/author | "Onishi I."xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/author | "Kirimura S."xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/author | "Abe-Suzuki S."xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/name | "Pathol Oncol Res"xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/pages | "399-407"xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/title | "Over-expression of cancerous inhibitor of PP2A (CIP2A) in bone marrow cells from patients with a group of high-risk myelodysplastic syndromes."xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/24163288 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24163288 |
| http://purl.uniprot.org/citations/24163288 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24163288 |
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| http://purl.uniprot.org/uniprot/#_Q8TCG1-mappedCitation-24163288 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24163288 |
| http://purl.uniprot.org/uniprot/Q8TCG1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24163288 |
| http://purl.uniprot.org/uniprot/A0A894J8Q9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24163288 |