| http://purl.uniprot.org/citations/24164540 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24164540 | http://www.w3.org/2000/01/rdf-schema#comment | "It is becoming increasingly clear that the T-cell-mediated immune response is important in many diseases. In this study, we used concanavalin A (Con A) -induced hepatitis to investigate the role of CD49a in the molecular and cellular mechanism of the T-cell-mediated immune response. We found that CD49a(-/-) mice had significantly reduced levels of serum alanine aminotransferase and were protected from Con A-induced hepatitis. CD49a deficiency led to decreased production of interferon-γ (IFN-γ) and interleukin-17A (IL-17A) after Con A injection. Furthermore, we found that hepatic CD4(+) T cells and invariant natural killer T cells up-regulated CD49a expression, along with enhanced activation after Con A injection, leading to production of inflammatory cytokines by these T cells. Blockade of CD49a in vivo ameliorated Con A-induced hepatitis with reduced production of IFN-γ and IL-17A. Hence, CD49a promoted Con A-induced hepatitis through enhancing inflammatory cytokine production (IFN-γ and IL-17A) by CD4(+) T and invariant natural killer T cells. The protective effect of CD49a blockade antibody suggested a new target therapeutic molecule for intervention of T-cell-mediated liver injury."xsd:string |
| http://purl.uniprot.org/citations/24164540 | http://purl.org/dc/terms/identifier | "doi:10.1111/imm.12201"xsd:string |
| http://purl.uniprot.org/citations/24164540 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/24164540 | http://purl.uniprot.org/core/author | "Sun R."xsd:string |
| http://purl.uniprot.org/citations/24164540 | http://purl.uniprot.org/core/author | "Tian Z."xsd:string |
| http://purl.uniprot.org/citations/24164540 | http://purl.uniprot.org/core/author | "Wei H."xsd:string |
| http://purl.uniprot.org/citations/24164540 | http://purl.uniprot.org/core/author | "Peng H."xsd:string |
| http://purl.uniprot.org/citations/24164540 | http://purl.uniprot.org/core/author | "Chen Y.'"xsd:string |
| http://purl.uniprot.org/citations/24164540 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24164540 | http://purl.uniprot.org/core/name | "Immunology"xsd:string |
| http://purl.uniprot.org/citations/24164540 | http://purl.uniprot.org/core/pages | "388-400"xsd:string |
| http://purl.uniprot.org/citations/24164540 | http://purl.uniprot.org/core/title | "CD49a promotes T-cell-mediated hepatitis by driving T helper 1 cytokine and interleukin-17 production."xsd:string |
| http://purl.uniprot.org/citations/24164540 | http://purl.uniprot.org/core/volume | "141"xsd:string |
| http://purl.uniprot.org/citations/24164540 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24164540 |
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