| http://purl.uniprot.org/citations/24166600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24166600 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular signal-regulated kinase (ERK1/2) is implicated in the malignant behavior of breast cancer cells. However, previous clinical-pathological studies have shown that expression of activated/phosphorylated ERK1/2 is not associated with enhanced proliferation and invasion of mammary carcinomas. ERK1/2 is expressed in the cytoplasm, and activated/phosphorylated ERK1/2 translocates to the nucleus. The aim of this study is to evaluate nuclear phosphorylated ERK1/2 as a biomarker for breast cancer prognosis. The clinical-pathological relation of cytoplasmic/nuclear phosphorylated ERK1/2 was analyzed in 105 surgically resected breast cancer specimens by immunohistochemistry with tissue microarray. The results showed that non-neoplastic breast tissue mainly showed faint phosphorylated ERK1/2 staining. No statistically significant association was found between the level of cytoplasmic phosphorylated ERK1/2 expression and the clinical features of the disease. High nuclear phosphorylated ERK1/2 expression was associated with high grade (poor differentiation, p = = 0.010), high T status (larger tumor size, p = 0.033), and an advanced stage (p = 0.018) of the disease. Thus, nuclear phosphorylated ERK1/2 is associated with enhanced proliferation and invasion of mammary carcinomas and may be a biomarker for breast cancer prognosis and the determination of therapeutic strategies."xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.org/dc/terms/identifier | "doi:10.5114/pjp.2013.38132"xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/author | "Hsu H.T."xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/author | "Chang C.C."xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/author | "Hsu P.C."xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/author | "Yeh C.M."xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/author | "Jiang M.C."xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/author | "Tai C.J."xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/author | "Kuo H.T."xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/author | "Shen K.H."xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/name | "Pol J Pathol"xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/pages | "163-169"xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/title | "High nuclear phosphorylated extracellular signal-regulated kinase expression associated with poor differentiation, larger tumor size, and an advanced stage of breast cancer."xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://purl.uniprot.org/core/volume | "64"xsd:string |
| http://purl.uniprot.org/citations/24166600 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24166600 |
| http://purl.uniprot.org/citations/24166600 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24166600 |
| http://purl.uniprot.org/uniprot/#_A1QJE5-mappedCitation-24166600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24166600 |
| http://purl.uniprot.org/uniprot/#_B4DHN0-mappedCitation-24166600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24166600 |
| http://purl.uniprot.org/uniprot/#_L7RXH5-mappedCitation-24166600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24166600 |
| http://purl.uniprot.org/uniprot/#_P27361-mappedCitation-24166600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24166600 |
| http://purl.uniprot.org/uniprot/#_Q1HBJ4-mappedCitation-24166600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24166600 |
| http://purl.uniprot.org/uniprot/#_P28482-mappedCitation-24166600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24166600 |
| http://purl.uniprot.org/uniprot/#_Q499G7-mappedCitation-24166600 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24166600 |