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http://purl.uniprot.org/citations/24175816http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24175816http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

High levels of bone morphogenetic protein (BMPs) have been reported in patients with lung cancer. This study was conducted to assess correlations between serum BMP-2 levels and prognostic outcome in patients with non-small-cell lung cancer (NSCLC).

Methods

Blood samples from 84 patients with advanced NSCLC and 42 healthy controls were analyzed and quantitated for serum BMP-2 levels before and after two cycles of chemotherapy using a commercially available ELISA kit.

Results

The median level of BMP-2 was 146.9 pg/ml in patients with NSCLC vs. 87.7 pg/ml in healthy controls (P<0.01). A significant correlation was observed between pretreatment serum BMP-2 level and ECOG PS, disease stage and number of organs with metastases (P<0.05). Serum BMP-2 level decreased significantly in patients who achieved objective response after two cycles of chemotherapy. Multivariate analysis showed that increased BMP-2 level and advanced clinical stage were significantly correlated with poor prognosis.

Conclusion

Thes erum BMP-2 level is positively correlated with clinical stage, ECOG PS and metastatic burden and may serve as an independent negative predictor for prognosis. Decreased BMP-2 after chemotherapy could be a reliable marker for efficacy of treatment."xsd:string
http://purl.uniprot.org/citations/24175816http://purl.org/dc/terms/identifier"doi:10.7314/apjcp.2013.14.9.5293"xsd:string
http://purl.uniprot.org/citations/24175816http://purl.uniprot.org/core/author"Yang X.L."xsd:string
http://purl.uniprot.org/citations/24175816http://purl.uniprot.org/core/author"Ma S.L."xsd:string
http://purl.uniprot.org/citations/24175816http://purl.uniprot.org/core/author"Yao C.Y."xsd:string
http://purl.uniprot.org/citations/24175816http://purl.uniprot.org/core/author"Huang X.E."xsd:string
http://purl.uniprot.org/citations/24175816http://purl.uniprot.org/core/author"Fei Z.H."xsd:string
http://purl.uniprot.org/citations/24175816http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/24175816http://purl.uniprot.org/core/name"Asian Pac J Cancer Prev"xsd:string
http://purl.uniprot.org/citations/24175816http://purl.uniprot.org/core/pages"5293-5299"xsd:string
http://purl.uniprot.org/citations/24175816http://purl.uniprot.org/core/title"Serum BMP-2 up-regulation as an indicator of poor survival in advanced non-small cell lung cancer patients."xsd:string
http://purl.uniprot.org/citations/24175816http://purl.uniprot.org/core/volume"14"xsd:string
http://purl.uniprot.org/citations/24175816http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/24175816
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