| http://purl.uniprot.org/citations/24179170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24179170 | http://www.w3.org/2000/01/rdf-schema#comment | "In relation to dietary Na(+) intake and aldosterone levels, collecting duct principal cells are exposed to large variations in Na(+) transport. In these cells, Na(+) crosses the apical membrane via epithelial Na(+) channels (ENaC) and is extruded into the interstitium by Na,K-ATPase. The activity of ENaC and Na,K-ATPase must be highly coordinated to accommodate variations in Na(+) transport and minimize fluctuations in intracellular Na(+) concentration. We hypothesized that, independent of hormonal stimulus, cross-talk between ENaC and Na,K-ATPase coordinates Na(+) transport across apical and basolateral membranes. By varying Na(+) intake in aldosterone-clamped rats and overexpressing γ-ENaC or modulating apical Na(+) availability in cultured mouse collecting duct cells, enhanced apical Na(+) entry invariably led to increased basolateral Na,K-ATPase expression and activity. In cultured collecting duct cells, enhanced apical Na(+) entry increased the basolateral cell surface expression of Na,K-ATPase by inhibiting p38 kinase-mediated endocytosis of Na,K-ATPase. Our results reveal a new role for p38 kinase in mediating cross-talk between apical Na(+) entry via ENaC and its basolateral exit via Na,K-ATPase, which may allow principal cells to maintain intracellular Na(+) concentrations within narrow limits."xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2013040429"xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/author | "Dizin E."xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/author | "Feraille E."xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/author | "Martin P.Y."xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/author | "Wang Y.B."xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/author | "Doucet A."xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/author | "Maunsbach A.B."xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/author | "Leroy V."xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/author | "Hasler U."xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/author | "de Seigneux S."xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/author | "Ernandez T."xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/pages | "250-259"xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/title | "Sodium transport is modulated by p38 kinase-dependent cross-talk between ENaC and Na,K-ATPase in collecting duct principal cells."xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/24179170 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24179170 |
| http://purl.uniprot.org/citations/24179170 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24179170 |
| http://purl.uniprot.org/uniprot/#_P70618-mappedCitation-24179170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24179170 |
| http://purl.uniprot.org/uniprot/#_A8C151-mappedCitation-24179170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24179170 |
| http://purl.uniprot.org/uniprot/#_A6JJR8-mappedCitation-24179170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24179170 |
| http://purl.uniprot.org/uniprot/#_A6I8V0-mappedCitation-24179170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24179170 |
| http://purl.uniprot.org/uniprot/#_G3V617-mappedCitation-24179170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24179170 |