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| http://purl.uniprot.org/citations/24183235 | http://www.w3.org/2000/01/rdf-schema#comment | "The t(5;17)(q35;q21) APL variant results in expression of a fusion protein linking the N-terminus of nucleophosmin (NPM) to the C-terminus of the retinoic acid receptor alpha (RAR). We have previously shown that NPM-RAR is capable of binding to DNA either as a homodimer or heterodimer with RXR. To determine the biological significance of NPM-RAR/RXR interaction, we developed two mutants of NPM-RAR that showed markedly diminished ability to bind RXR. U937 subclones expressing the NPM-RAR mutants showed significantly less inhibition of vitamin D3/TGFbeta-induced differentiation, compared with NPM-RAR. These results support the hypothesis that RXR interaction is necessary for NPM-RAR-mediated myeloid maturation arrest."xsd:string |
| http://purl.uniprot.org/citations/24183235 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.leukres.2013.09.024"xsd:string |
| http://purl.uniprot.org/citations/24183235 | http://purl.uniprot.org/core/author | "Redner R.L."xsd:string |
| http://purl.uniprot.org/citations/24183235 | http://purl.uniprot.org/core/author | "Rush E.A."xsd:string |
| http://purl.uniprot.org/citations/24183235 | http://purl.uniprot.org/core/author | "Abecassis I."xsd:string |
| http://purl.uniprot.org/citations/24183235 | http://purl.uniprot.org/core/author | "Pollock S.L."xsd:string |
| http://purl.uniprot.org/citations/24183235 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24183235 | http://purl.uniprot.org/core/name | "Leuk Res"xsd:string |
| http://purl.uniprot.org/citations/24183235 | http://purl.uniprot.org/core/pages | "1704-1710"xsd:string |
| http://purl.uniprot.org/citations/24183235 | http://purl.uniprot.org/core/title | "Interaction with RXR is necessary for NPM-RAR-induced myeloid differentiation blockade."xsd:string |
| http://purl.uniprot.org/citations/24183235 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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