| http://purl.uniprot.org/citations/24184560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24184560 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24184560 | http://www.w3.org/2000/01/rdf-schema#comment | "Foxn1 is essential for thymic organogenesis and T lymphopoiesis. Whereas reduced Foxn1 expression results in a decline in T lymphopoiesis, overexpression of Foxn1 in the thymus of a transgenic mouse model (Foxn1Tg) attenuates the age-associated decline in T lymphopoiesis. T lymphopoiesis begins with early T cell progenitors (ETP), derived from multipotent progenitors (MPP) in the bone marrow (BM). A decline in MPP and ETP numbers with age is thought to contribute to reduced T lymphopoiesis. Previously, we showed that reduced ETP number with age is attenuated in Foxn1 transgenic (Tg); whether the effect is initiated in the BM with MPP is not known. In this study, we report that Foxn1 is expressed in wild-type BM and overexpressed in Foxn1Tg. With age, the number of MPP in Foxn1Tg was not reduced, and Foxn1Tg also have a larger pool of hematopoietic stem cells. Furthermore, the Foxn1Tg BM is more efficient in generating MPP. In contrast to MPP, common lymphoid progenitors and B lineage cell numbers were significantly lower in both young and aged Foxn1Tg compared with wild type. We identified a novel population of lineage(neg/low), CD45(pos) EpCAM(pos), SCA1(pos), CD117(neg), CD138(neg), MHCII(neg) cells as Foxn1-expressing BM cells that also express Delta-like 4. Thus, Foxn1 affects both T lymphopoiesis and hematopoiesis, and the Foxn1 BM niche may function in skewing MPP development toward T lineage progenitors."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1202278"xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1202278"xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/author | "Gerstein R.M."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/author | "Gerstein R.M."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/author | "Le P.T."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/author | "Le P.T."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/author | "Witte P.L."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/author | "Witte P.L."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/author | "Zook E.C."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/author | "Zook E.C."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/pages | "5583-5593"xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/pages | "5583-5593"xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/title | "Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/title | "Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche."xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/24184560 | http://purl.uniprot.org/core/volume | "191"xsd:string |