| http://purl.uniprot.org/citations/24188822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24188822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24188822 | http://www.w3.org/2000/01/rdf-schema#comment | "ERp57 is a ubiquitous ER chaperone that has disulfide isomerase activity. Here, we found that both ERp57 and gastric H(+),K(+)-ATPase are expressed in a sample derived from the apical canalicular membranes of parietal cells. Overexpression of ERp57 in HEK293 cells stably expressing H(+),K(+)-ATPase significantly increased the ATPase activity without changing the expression level of H(+),K(+)-ATPase. Interestingly, overexpression of a catalytically inactive mutant of ERp57 (C57S/C60S/C406S/C409S) in the cells also increased H(+),K(+)-ATPase activity. In contrast, knockdown of endogenous ERp57 in H(+),K(+)-ATPase-expressing cells significantly decreased ATPase activity without changing the expression level of H(+),K(+)-ATPase. Overexpression and knockdown of ERp57 had no significant effect on the expression and function of Na(+),K(+)-ATPase. These results suggest that ERp57 positively regulates H(+),K(+)-ATPase activity apart from its chaperoning function."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2013.10.030"xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2013.10.030"xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Fujita K."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Fujita K."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Fujii T."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Fujii T."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Takahashi Y."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Takahashi Y."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Sakai H."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Sakai H."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Shimizu T."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Shimizu T."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Tsuji H."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Tsuji H."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Tsukada K."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Tsukada K."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Gomi T."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Gomi T."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Awaka S.Y."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/author | "Awaka S.Y."xsd:string |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24188822 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |