| http://purl.uniprot.org/citations/24190431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24190431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24190431 | http://www.w3.org/2000/01/rdf-schema#comment | "Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-antigens. We show how citrullinated aggrecan and vimentin epitopes bind to HLA-DRB1*04:01/04. Citrulline was accommodated within the electropositive P4 pocket of HLA-DRB1*04:01/04, whereas the electronegative P4 pocket of the RA-resistant HLA-DRB1*04:02 allomorph interacted with arginine or citrulline-containing epitopes. Peptide elution studies revealed P4 arginine-containing peptides from HLA-DRB1*04:02, but not from HLA-DRB1*04:01/04. Citrullination altered protease susceptibility of vimentin, thereby generating self-epitopes that are presented to T cells in HLA-DRB1*04:01(+) individuals. Using HLA-II tetramers, we observed citrullinated vimentin- and aggrecan-specific CD4(+) T cells in the peripheral blood of HLA-DRB1*04:01(+) RA-affected and healthy individuals. In RA patients, autoreactive T cell numbers correlated with disease activity and were deficient in regulatory T cells relative to healthy individuals. These findings reshape our understanding of the association between citrullination, the HLA-DRB1 locus, and T cell autoreactivity in RA."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20131241"xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20131241"xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Scally S.W."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Scally S.W."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Petersen J."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Petersen J."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Thomas R."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Thomas R."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Purcell A.W."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Purcell A.W."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Pike R.N."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Pike R.N."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Rossjohn J."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "McCluskey J."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Wijeyewickrema L.C."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Wijeyewickrema L.C."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Eckle S.B."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Eckle S.B."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Reid H.H."xsd:string |
| http://purl.uniprot.org/citations/24190431 | http://purl.uniprot.org/core/author | "Reid H.H."xsd:string |