| http://purl.uniprot.org/citations/24190517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24190517 | http://www.w3.org/2000/01/rdf-schema#comment | "New potential chemotherapeutic strategies are required to overcome multidrug resistance (MDR) in cancer. This study investigated the anticancer effect of a novel anthracene derivative MHY412 on doxorubicin-resistant human breast cancer (MCF-7/Adr) cells. We measured cell viability and the expression of apoptosis-related genes; in addition, the antitumor activity of MHY412 was confirmed using an in vivo tumor xenograft model. MHY412 significantly inhibited the proliferation of MCF-7/Adr and MCF-7 cells in a concentration-dependent manner. Notably, the half-maximal inhibitory concentration (IC50) values of MHY412 in MCF-7/Adr (0.15 µM) and MCF-7 (0.26 µM) cells were lower than those of doxorubicin (MCF-7/Adr, 13.6 µM and MCF-7, 1.26 µM) after treatment for 48 h. MHY412 at low concentrations induced S phase arrest, but at high concentrations, the number of MCF-7/Adr cells in the sub-G1 phase significantly increased. MHY412-induced sub-G1 phase arrest was associated with inhibition of cyclin, cyclin-dependent kinase 2 (CDK2) and p21 expression in MCF-7/Adr cells. MHY412 markedly reduced P-glycoprotein (P-gp) expression and increased apoptotic cell death in MCF-7/Adr cells. Cleavage of poly-ADP ribose polymerase, reduced Bcl-2 expression, and increased in cytochrome c release in MCF-7/Adr cells confirmed the above results. In addition, MHY412 markedly inhibited tumor growth in a tumor xenograft model of MCF-7/Adr cells. Our data suggest that MHY412 exerts antitumor effects by selectively modulating the genes related to cell cycle arrest and apoptosis. In particular, MHY412 is a new candidate agent for the treatment of Bcl-2 overexpressed doxorubicin-resistant human breast cancer."xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.org/dc/terms/identifier | "doi:10.3892/ijo.2013.2160"xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/author | "Jung J.H."xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/author | "Lee B.M."xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/author | "Kim N.D."xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/author | "Choi W.S."xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/author | "Chun P."xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/author | "De U."xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/author | "Moon H.R."xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/name | "Int J Oncol"xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/pages | "167-176"xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/title | "A novel anthracene derivative, MHY412, induces apoptosis in doxorubicin-resistant MCF-7/Adr human breast cancer cells through cell cycle arrest and downregulation of P-glycoprotein expression."xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/24190517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24190517 |
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