| http://purl.uniprot.org/citations/24204697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24204697 | http://www.w3.org/2000/01/rdf-schema#comment | "G-protein-coupled receptors (GPCR) are the largest family of cell surface molecules that play important role/s in a number of biological and pathological processes including cancers. Earlier studies have highlighted the importance of Wnt7a signaling via its cognate receptor Frizzled9, a GPCR, in inhibition of cell proliferation, anchorage-independent growth, and reversal of transformed phenotype in non small cell lung cancer primarily through activation of the tumor suppressor, PPARγ. However, the G-protein effectors that couple to this important tumor suppressor pathway have not been identified, and are of potential therapeutic interest. In this study, by using two independent Wnt7a/Frizzled9-specific read-outs, we identify Gα16 as a novel downstream effector of Wnt7a/Frizzled9 signaling. Interestingly, Gα16 expression is severely down-regulated, both at the messenger RNA levels and protein levels, in many non small cell lung cancer cell lines. Additionally, through gene-specific knock-downs and expression of GTPase-deficient forms (Q212L) of Gα16, we also establish Gα16 as a novel regulator of non small cell lung cancer cell proliferation and anchorage-independent cell growth. Taken together, our data not only establish the importance of Gα16 as a critical downstream effector of the non-canonical Wnt signaling pathway but also as a potential therapeutic target for the treatment of non small cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0076895"xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/author | "Sohn J.W."xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/author | "Byers J.T."xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/author | "Avasarala S."xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/author | "Bikkavilli R.K."xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/author | "Winn R.A."xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/author | "Heasley L.E."xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/author | "Van Scoyk M."xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/author | "Hostetter L."xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/author | "Lapite A."xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/pages | "e76895"xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/title | "Heterotrimeric G-protein, Galpha16, is a critical downstream effector of non-canonical Wnt signaling and a potent inhibitor of transformed cell growth in non small cell lung cancer."xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/24204697 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24204697 |
| http://purl.uniprot.org/citations/24204697 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24204697 |
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| http://purl.uniprot.org/uniprot/#_P30679-mappedCitation-24204697 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24204697 |
| http://purl.uniprot.org/uniprot/B4DU35 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24204697 |