| http://purl.uniprot.org/citations/24205214 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24205214 | http://www.w3.org/2000/01/rdf-schema#comment | "Mismatch repair (MMR) safeguards against genomic instability and is required for efficient Ig class switch recombination (CSR). Methyl CpG binding domain protein 4 (MBD4) binds to MutL homologue 1 (MLH1) and controls the post-transcriptional level of several MMR proteins, including MutS homologue 2 (MSH2). We show that in WT B cells activated for CSR, MBD4 is induced and interacts with MMR proteins, thereby implying a role for MBD4 in CSR. However, CSR is in the normal range in Mbd4 deficient mice deleted for exons 2-5 despite concomitant reduction of MSH2. We show by comparison in Msh2(+/-) B cells that a two-fold reduction of MSH2 and MBD4 proteins is correlated with impaired CSR. It is therefore surprising that CSR occurs at normal frequencies in the Mbd4 deficient B cells where MSH2 is reduced. We find that a variant Mbd4 transcript spanning exons 1,6-8 is expressed in Mbd4 deficient B cells. This transcript can be ectopically expressed and produces a truncated MBD4 peptide. Thus, the 3' end of the Mbd4 locus is not silent in Mbd4 deficient B cells and may contribute to CSR. Our findings highlight a complex relationship between MBD4 and MMR proteins in B cells and a potential reconsideration of their role in CSR."xsd:string |
| http://purl.uniprot.org/citations/24205214 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0078370"xsd:string |
| http://purl.uniprot.org/citations/24205214 | http://purl.uniprot.org/core/author | "Bellacosa A."xsd:string |
| http://purl.uniprot.org/citations/24205214 | http://purl.uniprot.org/core/author | "Kenter A.L."xsd:string |
| http://purl.uniprot.org/citations/24205214 | http://purl.uniprot.org/core/author | "Grigera F."xsd:string |
| http://purl.uniprot.org/citations/24205214 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24205214 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24205214 | http://purl.uniprot.org/core/pages | "e78370"xsd:string |
| http://purl.uniprot.org/citations/24205214 | http://purl.uniprot.org/core/title | "Complex relationship between mismatch repair proteins and MBD4 during immunoglobulin class switch recombination."xsd:string |
| http://purl.uniprot.org/citations/24205214 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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