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| http://purl.uniprot.org/citations/24209626 | http://www.w3.org/2000/01/rdf-schema#comment | "Reactivation of a silent transcriptional program is a critical step in successful axon regeneration following injury. Yet how such a program is unlocked after injury remains largely unexplored. We found that axon injury in peripheral sensory neurons elicits a back-propagating calcium wave that invades the soma and causes nuclear export of HDAC5 in a PKCμ-dependent manner. Injury-induced HDAC5 nuclear export enhances histone acetylation to activate a proregenerative gene-expression program. HDAC5 nuclear export is required for axon regeneration, as expression of a nuclear-trapped HDAC5 mutant prevents axon regeneration, whereas enhancing HDAC5 nuclear export promotes axon regeneration in vitro and in vivo. Components of this HDAC5 pathway failed to be activated in a model of central nervous system injury. These studies reveal a signaling mechanism from the axon injury site to the soma that controls neuronal growth competence and suggest a role for HDAC5 as a transcriptional switch controlling axon regeneration."xsd:string |
| http://purl.uniprot.org/citations/24209626 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.10.004"xsd:string |
| http://purl.uniprot.org/citations/24209626 | http://purl.uniprot.org/core/author | "Cho Y."xsd:string |
| http://purl.uniprot.org/citations/24209626 | http://purl.uniprot.org/core/author | "Cavalli V."xsd:string |
| http://purl.uniprot.org/citations/24209626 | http://purl.uniprot.org/core/author | "Sloutsky R."xsd:string |
| http://purl.uniprot.org/citations/24209626 | http://purl.uniprot.org/core/author | "Naegle K.M."xsd:string |
| http://purl.uniprot.org/citations/24209626 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24209626 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/24209626 | http://purl.uniprot.org/core/pages | "894-908"xsd:string |
| http://purl.uniprot.org/citations/24209626 | http://purl.uniprot.org/core/title | "Injury-induced HDAC5 nuclear export is essential for axon regeneration."xsd:string |
| http://purl.uniprot.org/citations/24209626 | http://purl.uniprot.org/core/volume | "155"xsd:string |
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