| http://purl.uniprot.org/citations/24209760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24209760 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms that regulate the establishment of adult stem cell pools during normal and perturbed mammalian development are still largely unknown. Here, we asked whether a maternal cytokine surge, which occurs during human maternal infections and has been implicated in cognitive disorders, might have long-lasting consequences for neural stem cell pools in adult progeny. We show that transient, maternally administered interleukin-6 (IL-6) resulted in an expanded adult forebrain neural precursor pool and perturbed olfactory neurogenesis in offspring months after fetal exposure. This increase is likely the long-term consequence of acute hyperactivation of an endogenous autocrine/paracrine IL-6-dependent self-renewal pathway that normally regulates the number of forebrain neural precursors. These studies therefore identify an IL-6-dependent neural stem cell self-renewal pathway in vivo, and support a model in which transiently increased maternal cytokines can act through this pathway in offspring to deregulate neural precursor biology from embryogenesis throughout life."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stem.2013.10.002"xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Yang G."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Kaplan D.R."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Miller F.D."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Cancino G.I."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Gallagher D."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Gauthier-Fisher A."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Woltjen K."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Fujitani M."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Vessey J.P."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Morshead C.M."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Woodard C.L."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Fatt M.P."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Norman A.A."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/author | "Sachewsky N."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/name | "Cell Stem Cell"xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/pages | "564-576"xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/title | "Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway."xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/24209760 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24209760 |
| http://purl.uniprot.org/citations/24209760 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24209760 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGF1-mappedCitation-24209760 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24209760 |