| http://purl.uniprot.org/citations/24211264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24211264 | http://www.w3.org/2000/01/rdf-schema#comment | "R loops are transcription byproducts that constitute a threat to genome integrity. Here we show that R loops are tightly linked to histone H3 S10 phosphorylation (H3S10P), a mark of chromatin condensation. Chromatin immunoprecipitation (ChIP)-on-chip (ChIP-chip) analyses reveal H3S10P accumulation at centromeres, pericentromeric chromatin, and a large number of active open reading frames (ORFs) in R-loop-accumulating yeast cells, better observed in G1. Histone H3S10 plays a key role in maintaining genome stability, as scored by ectopic recombination and plasmid loss, Rad52 foci, and Rad53 checkpoint activation. H3S10P coincides with the presence of DNA-RNA hybrids, is suppressed by ribonuclease H overexpression, and causes reduced accessibility of restriction endonucleases, implying a tight connection between R loops, H3S10P, and chromatin compaction. Such histone modifications were also observed in R-loop-accumulating Caenorhabditis elegans and HeLa cells. We therefore provide a role of RNA in chromatin structure essential to understand how R loops modulate genome dynamics."xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2013.10.006"xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/author | "Barroso S."xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/author | "Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/author | "Garcia-Muse T."xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/author | "Rondon A.G."xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/author | "Andujar E."xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/author | "Castellano-Pozo M."xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/author | "Perez-Alegre M."xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/author | "Santos-Pereira J.M."xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/pages | "583-590"xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/title | "R loops are linked to histone H3 S10 phosphorylation and chromatin condensation."xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/24211264 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24211264 |
| http://purl.uniprot.org/citations/24211264 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24211264 |
| http://purl.uniprot.org/uniprot/#_Q18033-mappedCitation-24211264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24211264 |
| http://purl.uniprot.org/uniprot/#_Q04740-mappedCitation-24211264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24211264 |
| http://purl.uniprot.org/uniprot/#_P17629-mappedCitation-24211264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24211264 |
| http://purl.uniprot.org/uniprot/Q04740 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24211264 |
| http://purl.uniprot.org/uniprot/P17629 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24211264 |
| http://purl.uniprot.org/uniprot/Q18033 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24211264 |